Role of TRPV1 in susceptibility to PTZ-induced seizure following repeated hyperthermia challenges in neonatal mice

Wei Lin Kong; Jia Wei Min; Yuan Lin Liu; Jun Xu Li; Xiao Hua He; Bi Wen Peng

doi:10.1016/j.yebeh.2013.10.022

Role of TRPV1 in susceptibility to PTZ-induced seizure following repeated hyperthermia challenges in neonatal mice

Wei Lin Kong
, Jia Wei Min
, Yuan Lin Liu
, Jun Xu Li
, Xiao Hua He
, Bi Wen Peng

Pharmacology and Toxicology

Wuhan University

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

This study was designed to investigate the role of experimental febrile seizures in the induction of generalized clonic seizures and the involvement of heat-sensitive channel TRPV1. Pentylenetetrazol-induced clonic seizure was used as the seizure model, and Trpv1 gene knock-out and wild-type C57/BL6 mice were used as experimental subjects. Electroencephalograph and seizure behavior were recorded for the evaluation of the severity of seizures.Increased frequency of the experimental febrile seizures facilitated PTZ-induced generalized clonic seizures. Trpv1 gene deficiency decreased the properties of generalized clonic seizure. The intensity of experimental febrile seizures reduced the threshold to generalized clonic seizure, and Trpv1 gene deficiency decreased the susceptibility to PTZ-induced seizures following early-life hyperthermia challenges in mice.

Original language	English
Pages (from-to)	276-280
Number of pages	5
Journal	Epilepsy and Behavior
Volume	31
DOIs	https://doi.org/10.1016/j.yebeh.2013.10.022
State	Published - Feb 2014

Keywords

EEG
Epilepsy
Repetitive febrile seizures
TRPV1

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10.1016/j.yebeh.2013.10.022

Cite this

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title = "Role of TRPV1 in susceptibility to PTZ-induced seizure following repeated hyperthermia challenges in neonatal mice",

abstract = "This study was designed to investigate the role of experimental febrile seizures in the induction of generalized clonic seizures and the involvement of heat-sensitive channel TRPV1. Pentylenetetrazol-induced clonic seizure was used as the seizure model, and Trpv1 gene knock-out and wild-type C57/BL6 mice were used as experimental subjects. Electroencephalograph and seizure behavior were recorded for the evaluation of the severity of seizures.Increased frequency of the experimental febrile seizures facilitated PTZ-induced generalized clonic seizures. Trpv1 gene deficiency decreased the properties of generalized clonic seizure. The intensity of experimental febrile seizures reduced the threshold to generalized clonic seizure, and Trpv1 gene deficiency decreased the susceptibility to PTZ-induced seizures following early-life hyperthermia challenges in mice.",

keywords = "EEG, Epilepsy, Repetitive febrile seizures, TRPV1",

author = "Kong, \{Wei Lin\} and Min, \{Jia Wei\} and Liu, \{Yuan Lin\} and Li, \{Jun Xu\} and He, \{Xiao Hua\} and Peng, \{Bi Wen\}",

year = "2014",

month = feb,

doi = "10.1016/j.yebeh.2013.10.022",

language = "English",

volume = "31",

pages = "276--280",

journal = "Epilepsy and Behavior",

issn = "1525-5050",

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T1 - Role of TRPV1 in susceptibility to PTZ-induced seizure following repeated hyperthermia challenges in neonatal mice

AU - Kong, Wei Lin

AU - Min, Jia Wei

AU - Liu, Yuan Lin

AU - Li, Jun Xu

AU - He, Xiao Hua

AU - Peng, Bi Wen

PY - 2014/2

Y1 - 2014/2

N2 - This study was designed to investigate the role of experimental febrile seizures in the induction of generalized clonic seizures and the involvement of heat-sensitive channel TRPV1. Pentylenetetrazol-induced clonic seizure was used as the seizure model, and Trpv1 gene knock-out and wild-type C57/BL6 mice were used as experimental subjects. Electroencephalograph and seizure behavior were recorded for the evaluation of the severity of seizures.Increased frequency of the experimental febrile seizures facilitated PTZ-induced generalized clonic seizures. Trpv1 gene deficiency decreased the properties of generalized clonic seizure. The intensity of experimental febrile seizures reduced the threshold to generalized clonic seizure, and Trpv1 gene deficiency decreased the susceptibility to PTZ-induced seizures following early-life hyperthermia challenges in mice.

AB - This study was designed to investigate the role of experimental febrile seizures in the induction of generalized clonic seizures and the involvement of heat-sensitive channel TRPV1. Pentylenetetrazol-induced clonic seizure was used as the seizure model, and Trpv1 gene knock-out and wild-type C57/BL6 mice were used as experimental subjects. Electroencephalograph and seizure behavior were recorded for the evaluation of the severity of seizures.Increased frequency of the experimental febrile seizures facilitated PTZ-induced generalized clonic seizures. Trpv1 gene deficiency decreased the properties of generalized clonic seizure. The intensity of experimental febrile seizures reduced the threshold to generalized clonic seizure, and Trpv1 gene deficiency decreased the susceptibility to PTZ-induced seizures following early-life hyperthermia challenges in mice.

KW - EEG

KW - Epilepsy

KW - Repetitive febrile seizures

KW - TRPV1

UR - https://www.scopus.com/pages/publications/84892960675

U2 - 10.1016/j.yebeh.2013.10.022

DO - 10.1016/j.yebeh.2013.10.022

M3 - Article

C2 - 24269027

AN - SCOPUS:84892960675

SN - 1525-5050

VL - 31

SP - 276

EP - 280

JO - Epilepsy and Behavior

JF - Epilepsy and Behavior

ER -

Role of TRPV1 in susceptibility to PTZ-induced seizure following repeated hyperthermia challenges in neonatal mice

Abstract

Keywords

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