Role of serologic and molecular diagnostic assays in identification and management of hepatitis c virus infection

Gavin Cloherty; Andrew Talal; Kelly Coller; Corklin Steinhart; John Hackett; George Dawson; Juergen Rockstroh; Jordan Feld

doi:10.1128/JCM.02407-15

Role of serologic and molecular diagnostic assays in identification and management of hepatitis c virus infection

Gavin Cloherty
, Andrew Talal
, Kelly Coller
, Corklin Steinhart
, John Hackett
, George Dawson
, Juergen Rockstroh
, Jordan Feld

Medicine

Abbott Diagnostics
GlaxoSmithKline
University of Bonn
University of Toronto

Research output: Contribution to journal › Review article › peer-review

41 Scopus citations

Abstract

The drugs available for the treatment of hepatitis C virus (HCV) have evolved to provide shorter treatment duration and higher rates of sustained virologic response (SVR), and the role of HCV infection diagnostic tests has had to evolve in order to meet changing clinical needs. This review gives an overview on the role of HCV infection diagnostic testing (molecular and serological tools) used in the diagnosis and management of HCV infection. All of this critical information guides physician decisions to optimize patient clinical outcomes. Also discussed is the future direction of diagnostic testing in the context of further advances in drug development.

Original language	English
Pages (from-to)	265-273
Number of pages	9
Journal	Journal of Clinical Microbiology
Volume	54
Issue number	2
DOIs	https://doi.org/10.1128/JCM.02407-15
State	Published - Feb 2016

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abstract = "The drugs available for the treatment of hepatitis C virus (HCV) have evolved to provide shorter treatment duration and higher rates of sustained virologic response (SVR), and the role of HCV infection diagnostic tests has had to evolve in order to meet changing clinical needs. This review gives an overview on the role of HCV infection diagnostic testing (molecular and serological tools) used in the diagnosis and management of HCV infection. All of this critical information guides physician decisions to optimize patient clinical outcomes. Also discussed is the future direction of diagnostic testing in the context of further advances in drug development.",

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AU - Cloherty, Gavin

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AU - Coller, Kelly

AU - Steinhart, Corklin

AU - Hackett, John

AU - Dawson, George

AU - Rockstroh, Juergen

AU - Feld, Jordan

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AB - The drugs available for the treatment of hepatitis C virus (HCV) have evolved to provide shorter treatment duration and higher rates of sustained virologic response (SVR), and the role of HCV infection diagnostic tests has had to evolve in order to meet changing clinical needs. This review gives an overview on the role of HCV infection diagnostic testing (molecular and serological tools) used in the diagnosis and management of HCV infection. All of this critical information guides physician decisions to optimize patient clinical outcomes. Also discussed is the future direction of diagnostic testing in the context of further advances in drug development.

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Role of serologic and molecular diagnostic assays in identification and management of hepatitis c virus infection

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