Role of Paraoxonase 1 as an Antioxidant in Nonalcoholic Steatohepatitis

Sarita Singhal; Susan S. Baker; Robert D. Baker; Lixin Zhu

doi:10.1016/B978-0-12-803951-9.00002-1

Role of Paraoxonase 1 as an Antioxidant in Nonalcoholic Steatohepatitis

Sarita Singhal
, Susan S. Baker
, Robert D. Baker
, Lixin Zhu

Pediatrics

SUNY Buffalo

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

2 Scopus citations

Abstract

Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are leading causes of liver diseases in children as well as adults. Oxidative stress is recognized as an underlying mechanism for the progression of this condition. Several studies are being conducted with an aim to explain molecular pathological mechanism of NASH that could help identify important targets for therapeutic or preventive interventions for NASH patients. Paraoxonase (PON) 1 is an enzyme that is known for its role as an antioxidant in cardiovascular disease. This enzyme is synthesized in liver and is found in circulation bound to HDL. Recent studies have investigated its role in liver diseases, such as chronic hepatitis, hepatocellular carcinoma, acute viral hepatitis, chronic alcoholic disease, and NASH. This chapter summarizes PON enzymes structure and function, and its role in liver diseases that are mediated through oxidative stress.

Original language	English
Title of host publication	The Liver
Subtitle of host publication	Oxidative Stress and Dietary Antioxidants
Publisher	Elsevier
Pages	15-20
Number of pages	6
ISBN (Electronic)	9780128039519
DOIs	https://doi.org/10.1016/B978-0-12-803951-9.00002-1
State	Published - Jan 1 2018

Keywords

Antioxidant
NAFLD
NASH
Oxidative stress
PON1

Access to Document

10.1016/B978-0-12-803951-9.00002-1

Cite this

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title = "Role of Paraoxonase 1 as an Antioxidant in Nonalcoholic Steatohepatitis",

abstract = "Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are leading causes of liver diseases in children as well as adults. Oxidative stress is recognized as an underlying mechanism for the progression of this condition. Several studies are being conducted with an aim to explain molecular pathological mechanism of NASH that could help identify important targets for therapeutic or preventive interventions for NASH patients. Paraoxonase (PON) 1 is an enzyme that is known for its role as an antioxidant in cardiovascular disease. This enzyme is synthesized in liver and is found in circulation bound to HDL. Recent studies have investigated its role in liver diseases, such as chronic hepatitis, hepatocellular carcinoma, acute viral hepatitis, chronic alcoholic disease, and NASH. This chapter summarizes PON enzymes structure and function, and its role in liver diseases that are mediated through oxidative stress.",

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AU - Zhu, Lixin

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N2 - Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are leading causes of liver diseases in children as well as adults. Oxidative stress is recognized as an underlying mechanism for the progression of this condition. Several studies are being conducted with an aim to explain molecular pathological mechanism of NASH that could help identify important targets for therapeutic or preventive interventions for NASH patients. Paraoxonase (PON) 1 is an enzyme that is known for its role as an antioxidant in cardiovascular disease. This enzyme is synthesized in liver and is found in circulation bound to HDL. Recent studies have investigated its role in liver diseases, such as chronic hepatitis, hepatocellular carcinoma, acute viral hepatitis, chronic alcoholic disease, and NASH. This chapter summarizes PON enzymes structure and function, and its role in liver diseases that are mediated through oxidative stress.

AB - Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are leading causes of liver diseases in children as well as adults. Oxidative stress is recognized as an underlying mechanism for the progression of this condition. Several studies are being conducted with an aim to explain molecular pathological mechanism of NASH that could help identify important targets for therapeutic or preventive interventions for NASH patients. Paraoxonase (PON) 1 is an enzyme that is known for its role as an antioxidant in cardiovascular disease. This enzyme is synthesized in liver and is found in circulation bound to HDL. Recent studies have investigated its role in liver diseases, such as chronic hepatitis, hepatocellular carcinoma, acute viral hepatitis, chronic alcoholic disease, and NASH. This chapter summarizes PON enzymes structure and function, and its role in liver diseases that are mediated through oxidative stress.

KW - Antioxidant

KW - NAFLD

KW - NASH

KW - Oxidative stress

KW - PON1

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BT - The Liver

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ER -

Role of Paraoxonase 1 as an Antioxidant in Nonalcoholic Steatohepatitis

Abstract

Keywords

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