Role of MHC II affinity and molecular mimicry in defining anti-HER-2/neu MAb-3 linear peptide epitope

Alberta Lucchese; Stefan Stevanovic; Animesh A. Sinha; Abraham Mittelman; Darja Kanduc

doi:10.1016/S0196-9781(03)00026-3

Role of MHC II affinity and molecular mimicry in defining anti-HER-2/neu MAb-3 linear peptide epitope

Alberta Lucchese
, Stefan Stevanovic
, Animesh A. Sinha
, Abraham Mittelman
, Darja Kanduc

Department of Dermatology

CARSO Cancer Research Center
University of Tübingen
New York Medical College

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

With the aid of computational biology, we have studied the possibility of predicting the peptides able to evoke humoral immune response by using as experimental model the human HER-2/neu breast cancer-associated antigen. We already demonstrated that HER-2/neu peptides, that are the target of humoral human and mouse immune responses, correspond to those sequences having a low degree of sequence similarity to host's proteome. Here we report that the linear peptide determinant of the anti-HER-2/neu MAb-3 is characterized by a low degree of sequence similarity to mouse proteome in combination with high binding potential to specific MHC II molecule.

Original language	English
Pages (from-to)	193-197
Number of pages	5
Journal	Peptides
Volume	24
Issue number	2
DOIs	https://doi.org/10.1016/S0196-9781(03)00026-3
State	Published - Feb 1 2003

Keywords

Computational biology
Epitope prediction
HER-2/neu
MHC binding potential
Molecular mimicry

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10.1016/S0196-9781(03)00026-3

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abstract = "With the aid of computational biology, we have studied the possibility of predicting the peptides able to evoke humoral immune response by using as experimental model the human HER-2/neu breast cancer-associated antigen. We already demonstrated that HER-2/neu peptides, that are the target of humoral human and mouse immune responses, correspond to those sequences having a low degree of sequence similarity to host's proteome. Here we report that the linear peptide determinant of the anti-HER-2/neu MAb-3 is characterized by a low degree of sequence similarity to mouse proteome in combination with high binding potential to specific MHC II molecule.",

keywords = "Computational biology, Epitope prediction, HER-2/neu, MHC binding potential, Molecular mimicry",

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AU - Lucchese, Alberta

AU - Stevanovic, Stefan

AU - Sinha, Animesh A.

AU - Mittelman, Abraham

AU - Kanduc, Darja

PY - 2003/2/1

Y1 - 2003/2/1

N2 - With the aid of computational biology, we have studied the possibility of predicting the peptides able to evoke humoral immune response by using as experimental model the human HER-2/neu breast cancer-associated antigen. We already demonstrated that HER-2/neu peptides, that are the target of humoral human and mouse immune responses, correspond to those sequences having a low degree of sequence similarity to host's proteome. Here we report that the linear peptide determinant of the anti-HER-2/neu MAb-3 is characterized by a low degree of sequence similarity to mouse proteome in combination with high binding potential to specific MHC II molecule.

AB - With the aid of computational biology, we have studied the possibility of predicting the peptides able to evoke humoral immune response by using as experimental model the human HER-2/neu breast cancer-associated antigen. We already demonstrated that HER-2/neu peptides, that are the target of humoral human and mouse immune responses, correspond to those sequences having a low degree of sequence similarity to host's proteome. Here we report that the linear peptide determinant of the anti-HER-2/neu MAb-3 is characterized by a low degree of sequence similarity to mouse proteome in combination with high binding potential to specific MHC II molecule.

KW - Computational biology

KW - Epitope prediction

KW - HER-2/neu

KW - MHC binding potential

KW - Molecular mimicry

UR - https://www.scopus.com/pages/publications/0037302369

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DO - 10.1016/S0196-9781(03)00026-3

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AN - SCOPUS:0037302369

SN - 0196-9781

VL - 24

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EP - 197

JO - Peptides

JF - Peptides

IS - 2

ER -

Role of MHC II affinity and molecular mimicry in defining anti-HER-2/neu MAb-3 linear peptide epitope

Abstract

Keywords

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