Role of endogenous and induced regulatory T cells during infections

Elizabeth Wohlfert; Yasmine Belkaid

doi:10.1007/s10875-008-9248-6

Role of endogenous and induced regulatory T cells during infections

Elizabeth Wohlfert
, Yasmine Belkaid

Microbiology and Immunology

National Institutes of Health

Research output: Contribution to journal › Review article › peer-review

46 Scopus citations

Abstract

Background: Various populations of regulatory cells, including Foxp3+ T_Reg, have been shown to play a central role in the maintenance of peripheral homeostasis and establishment of controlled immune responses. Objective: In this review, we discuss current hypotheses and points of polemic associated with the origin, mode of action, and antigen specificity of both endogenous and induced regulatory T cells during infections.

Original language	English
Pages (from-to)	707-715
Number of pages	9
Journal	Journal of Clinical Immunology
Volume	28
Issue number	6
DOIs	https://doi.org/10.1007/s10875-008-9248-6
State	Published - Nov 2008

Keywords

Controlled immune response
Peripheral homeostasis
Regulatory T cells

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10.1007/s10875-008-9248-6

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title = "Role of endogenous and induced regulatory T cells during infections",

abstract = "Background: Various populations of regulatory cells, including Foxp3+ TReg, have been shown to play a central role in the maintenance of peripheral homeostasis and establishment of controlled immune responses. Objective: In this review, we discuss current hypotheses and points of polemic associated with the origin, mode of action, and antigen specificity of both endogenous and induced regulatory T cells during infections.",

keywords = "Controlled immune response, Peripheral homeostasis, Regulatory T cells",

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AU - Wohlfert, Elizabeth

AU - Belkaid, Yasmine

PY - 2008/11

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N2 - Background: Various populations of regulatory cells, including Foxp3+ TReg, have been shown to play a central role in the maintenance of peripheral homeostasis and establishment of controlled immune responses. Objective: In this review, we discuss current hypotheses and points of polemic associated with the origin, mode of action, and antigen specificity of both endogenous and induced regulatory T cells during infections.

AB - Background: Various populations of regulatory cells, including Foxp3+ TReg, have been shown to play a central role in the maintenance of peripheral homeostasis and establishment of controlled immune responses. Objective: In this review, we discuss current hypotheses and points of polemic associated with the origin, mode of action, and antigen specificity of both endogenous and induced regulatory T cells during infections.

KW - Controlled immune response

KW - Peripheral homeostasis

KW - Regulatory T cells

UR - https://www.scopus.com/pages/publications/56649105150

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DO - 10.1007/s10875-008-9248-6

M3 - Review article

C2 - 18810611

AN - SCOPUS:56649105150

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VL - 28

SP - 707

EP - 715

JO - Journal of Clinical Immunology

JF - Journal of Clinical Immunology

IS - 6

ER -

Role of endogenous and induced regulatory T cells during infections

Abstract

Keywords

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