Risch's lambda values for human obesity

D. B. Allison; M. S. Faith; J. S. Nathan

Risch's lambda values for human obesity

D. B. Allison
, M. S. Faith
, J. S. Nathan

Counseling, School and Educational Psychology

Columbia University
Continuum Health Partners, Inc.

Research output: Contribution to journal › Article › peer-review

90 Scopus citations

Abstract

OBJECTIVE: Risch's lambda statistic (λ(R)) is related to the heritability of traits and can be useful in several contexts, including the conduct of power analyses to determine sample size for gene mapping studies. However, values of λ(R) have not been presented for human obesity. DESIGN AND RESULTS: Using both analytic and empirical approaches, the present study calculates estimates of λ(R) Examples are provided to illustrate the use of these estimates for determining sample size for genetic mapping studies.

Original language	English
Pages (from-to)	990-999
Number of pages	10
Journal	International Journal of Obesity
Volume	20
Issue number	11
State	Published - 1996

Keywords

Affected relative pairs
Leanness
Linkage studies
Obesity
Statistical power
Thresholds

Cite this

@article{c0312b39c187472891747e529d8d597d,

title = "Risch's lambda values for human obesity",

abstract = "OBJECTIVE: Risch's lambda statistic (λ(R)) is related to the heritability of traits and can be useful in several contexts, including the conduct of power analyses to determine sample size for gene mapping studies. However, values of λ(R) have not been presented for human obesity. DESIGN AND RESULTS: Using both analytic and empirical approaches, the present study calculates estimates of λ(R) Examples are provided to illustrate the use of these estimates for determining sample size for genetic mapping studies.",

keywords = "Affected relative pairs, Leanness, Linkage studies, Obesity, Statistical power, Thresholds",

author = "Allison, \{D. B.\} and Faith, \{M. S.\} and Nathan, \{J. S.\}",

year = "1996",

language = "English",

volume = "20",

pages = "990--999",

journal = "International Journal of Obesity",

issn = "0307-0565",

publisher = "Springer Nature",

number = "11",

}

TY - JOUR

T1 - Risch's lambda values for human obesity

AU - Allison, D. B.

AU - Faith, M. S.

AU - Nathan, J. S.

PY - 1996

Y1 - 1996

N2 - OBJECTIVE: Risch's lambda statistic (λ(R)) is related to the heritability of traits and can be useful in several contexts, including the conduct of power analyses to determine sample size for gene mapping studies. However, values of λ(R) have not been presented for human obesity. DESIGN AND RESULTS: Using both analytic and empirical approaches, the present study calculates estimates of λ(R) Examples are provided to illustrate the use of these estimates for determining sample size for genetic mapping studies.

AB - OBJECTIVE: Risch's lambda statistic (λ(R)) is related to the heritability of traits and can be useful in several contexts, including the conduct of power analyses to determine sample size for gene mapping studies. However, values of λ(R) have not been presented for human obesity. DESIGN AND RESULTS: Using both analytic and empirical approaches, the present study calculates estimates of λ(R) Examples are provided to illustrate the use of these estimates for determining sample size for genetic mapping studies.

KW - Affected relative pairs

KW - Leanness

KW - Linkage studies

KW - Obesity

KW - Statistical power

KW - Thresholds

UR - https://www.scopus.com/pages/publications/0029962652

M3 - Article

C2 - 8923155

AN - SCOPUS:0029962652

SN - 0307-0565

VL - 20

SP - 990

EP - 999

JO - International Journal of Obesity

JF - International Journal of Obesity

IS - 11

ER -

Risch's lambda values for human obesity

Abstract

Keywords

Other files and links

Fingerprint

Cite this