Ribosome Assembly in Trypanosomatids: A Novel Therapeutic Target

Anyango D. Kamina; Noreen Williams

doi:10.1016/j.pt.2016.12.003

Ribosome Assembly in Trypanosomatids: A Novel Therapeutic Target

Research output: Contribution to journal › Short survey › peer-review

6 Scopus citations

Abstract

In Liu et al., the authors present a 2.5-Å structure of the Trypanosoma cruzi 60S ribosomal subunit and propose a model for the stepwise assembly of the large-subunit ribosomal RNA (rRNA). Based on this study, we discuss how the unique features of trypanosomatid ribosome assembly offer potential drug targets.

Original language	English
Pages (from-to)	256-257
Number of pages	2
Journal	Trends in Parasitology
Volume	33
Issue number	4
DOIs	https://doi.org/10.1016/j.pt.2016.12.003
State	Published - Apr 1 2017

Keywords

ribosome assembly
ribosome structure.
rRNA processing
trypanosomatids

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10.1016/j.pt.2016.12.003

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title = "Ribosome Assembly in Trypanosomatids: A Novel Therapeutic Target",

abstract = "In Liu et al., the authors present a 2.5-{\AA} structure of the Trypanosoma cruzi 60S ribosomal subunit and propose a model for the stepwise assembly of the large-subunit ribosomal RNA (rRNA). Based on this study, we discuss how the unique features of trypanosomatid ribosome assembly offer potential drug targets.",

keywords = "ribosome assembly, ribosome structure., rRNA processing, trypanosomatids",

author = "Kamina, \{Anyango D.\} and Noreen Williams",

note = "Publisher Copyright: {\textcopyright} 2016 Elsevier Ltd",

year = "2017",

month = apr,

day = "1",

doi = "10.1016/j.pt.2016.12.003",

language = "English",

volume = "33",

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journal = "Trends in Parasitology",

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TY - JOUR

T1 - Ribosome Assembly in Trypanosomatids

T2 - A Novel Therapeutic Target

AU - Kamina, Anyango D.

AU - Williams, Noreen

PY - 2017/4/1

Y1 - 2017/4/1

N2 - In Liu et al., the authors present a 2.5-Å structure of the Trypanosoma cruzi 60S ribosomal subunit and propose a model for the stepwise assembly of the large-subunit ribosomal RNA (rRNA). Based on this study, we discuss how the unique features of trypanosomatid ribosome assembly offer potential drug targets.

AB - In Liu et al., the authors present a 2.5-Å structure of the Trypanosoma cruzi 60S ribosomal subunit and propose a model for the stepwise assembly of the large-subunit ribosomal RNA (rRNA). Based on this study, we discuss how the unique features of trypanosomatid ribosome assembly offer potential drug targets.

KW - ribosome assembly

KW - ribosome structure.

KW - rRNA processing

KW - trypanosomatids

UR - https://www.scopus.com/pages/publications/85007572090

U2 - 10.1016/j.pt.2016.12.003

DO - 10.1016/j.pt.2016.12.003

M3 - Short survey

C2 - 27988096

AN - SCOPUS:85007572090

SN - 1471-4922

VL - 33

SP - 256

EP - 257

JO - Trends in Parasitology

JF - Trends in Parasitology

IS - 4

ER -

Ribosome Assembly in Trypanosomatids: A Novel Therapeutic Target

Abstract

Keywords

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