Ribosomal RNA Processing

K. Umaer; M. Ciganda; N. Williams

doi:10.1016/B978-0-12-394447-4.30039-6

Ribosomal RNA Processing

K. Umaer
, M. Ciganda
, N. Williams

Microbiology and Immunology

SUNY Buffalo

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

2 Scopus citations

Abstract

Ribosomal RNAs are heavily processed and modified before they become mature constituents of ribosomes. This essential process begins in the nucleolus and is completed in the cytoplasm. Enzymatic processing by exo and endonucleases removes spacers between coding sequences. Specific residues are chemically modified by pseudouridylation or methylation. These modifications are mediated by interactions with small nucleolar RNAs. Folding of the precursors is important for enzyme recognition and activity. This article describes in detail our current knowledge of the rRNA processing pathway in Saccharomyces cerevisiae and Escherichia coli, and the manner in which mammals and other eukaryotes differ most strikingly.

Original language	English
Title of host publication	Functional Cell Biology
Publisher	Elsevier Inc.
Pages	288-296
Number of pages	9
Volume	3
ISBN (Electronic)	9780123944474
ISBN (Print)	9780123947963
DOIs	https://doi.org/10.1016/B978-0-12-394447-4.30039-6
State	Published - 2016

Keywords

18S rRNA
23S rRNA
25/28S rRNA
5.8S rRNA
5S rRNA
Endonuclease
Exonuclease
Human diseases
Ribosomal RNA
Ribosomes
RRNA processing

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10.1016/B978-0-12-394447-4.30039-6

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title = "Ribosomal RNA Processing",

abstract = "Ribosomal RNAs are heavily processed and modified before they become mature constituents of ribosomes. This essential process begins in the nucleolus and is completed in the cytoplasm. Enzymatic processing by exo and endonucleases removes spacers between coding sequences. Specific residues are chemically modified by pseudouridylation or methylation. These modifications are mediated by interactions with small nucleolar RNAs. Folding of the precursors is important for enzyme recognition and activity. This article describes in detail our current knowledge of the rRNA processing pathway in Saccharomyces cerevisiae and Escherichia coli, and the manner in which mammals and other eukaryotes differ most strikingly.",

keywords = "18S rRNA, 23S rRNA, 25/28S rRNA, 5.8S rRNA, 5S rRNA, Endonuclease, Exonuclease, Human diseases, Ribosomal RNA, Ribosomes, RRNA processing",

author = "K. Umaer and M. Ciganda and N. Williams",

year = "2016",

doi = "10.1016/B978-0-12-394447-4.30039-6",

language = "English",

isbn = "9780123947963",

volume = "3",

pages = "288--296",

booktitle = "Functional Cell Biology",

publisher = "Elsevier Inc.",

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TY - CHAP

T1 - Ribosomal RNA Processing

AU - Umaer, K.

AU - Ciganda, M.

AU - Williams, N.

PY - 2016

Y1 - 2016

N2 - Ribosomal RNAs are heavily processed and modified before they become mature constituents of ribosomes. This essential process begins in the nucleolus and is completed in the cytoplasm. Enzymatic processing by exo and endonucleases removes spacers between coding sequences. Specific residues are chemically modified by pseudouridylation or methylation. These modifications are mediated by interactions with small nucleolar RNAs. Folding of the precursors is important for enzyme recognition and activity. This article describes in detail our current knowledge of the rRNA processing pathway in Saccharomyces cerevisiae and Escherichia coli, and the manner in which mammals and other eukaryotes differ most strikingly.

AB - Ribosomal RNAs are heavily processed and modified before they become mature constituents of ribosomes. This essential process begins in the nucleolus and is completed in the cytoplasm. Enzymatic processing by exo and endonucleases removes spacers between coding sequences. Specific residues are chemically modified by pseudouridylation or methylation. These modifications are mediated by interactions with small nucleolar RNAs. Folding of the precursors is important for enzyme recognition and activity. This article describes in detail our current knowledge of the rRNA processing pathway in Saccharomyces cerevisiae and Escherichia coli, and the manner in which mammals and other eukaryotes differ most strikingly.

KW - 18S rRNA

KW - 23S rRNA

KW - 25/28S rRNA

KW - 5.8S rRNA

KW - 5S rRNA

KW - Endonuclease

KW - Exonuclease

KW - Human diseases

KW - Ribosomal RNA

KW - Ribosomes

KW - RRNA processing

UR - https://www.scopus.com/pages/publications/85019401526

U2 - 10.1016/B978-0-12-394447-4.30039-6

DO - 10.1016/B978-0-12-394447-4.30039-6

M3 - Chapter

AN - SCOPUS:85019401526

SN - 9780123947963

VL - 3

SP - 288

EP - 296

BT - Functional Cell Biology

PB - Elsevier Inc.

ER -

Ribosomal RNA Processing

Abstract

Keywords

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