Abstract
Translational frameshifting sometimes occurs when ribosomes encounter a "shift" site preceding a region of unusual secondary structure, which in at least three cases is known to be a pseudoknot. We provide evidence that ribosomes have a decreased rate of movement through a pseudoknot required for frameshifting. These paused ribosomes are directly situated over the shift sequence. Ribosomal pausing appears to be necessary but not sufficient for frameshifting.
| Original language | English |
|---|---|
| Pages (from-to) | 8636-8640 |
| Number of pages | 5 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Volume | 89 |
| Issue number | 18 |
| State | Published - 1992 |
Keywords
- Double-stranded RNA virus
- Saccharomyces cerevisiae virus
- Translation
- Yeast
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