Review Rethinking the Role of DISC1 in CNS Function: Translational Cross-Taxon Insights From Rodent and Zebrafish Models

Andrey D. Volgin; Sergey V. Cheresiz; Nadezhda D. Chizhova; Kristina V. Smirnova; Alexey V. Doroshkov; David S. Galstya; Murilo S. de Abreu; Tatyana Strekalova; Tatiana Lipina; Mikhail Pletnikov; Longen Yang; Lee Wei Lim; Adam Michael Stewart; Tamara G. Amstislavskaya; Allan V. Kalueff

doi:10.31083/JIN43162

Review Rethinking the Role of DISC1 in CNS Function: Translational Cross-Taxon Insights From Rodent and Zebrafish Models

Andrey D. Volgin
, Sergey V. Cheresiz
, Nadezhda D. Chizhova
, Kristina V. Smirnova
, Alexey V. Doroshkov
, David S. Galstya
, Murilo S. de Abreu
, Tatyana Strekalova
, Tatiana Lipina
, Mikhail Pletnikov
, Longen Yang
, Lee Wei Lim
, Adam Michael Stewart
, Tamara G. Amstislavskaya
, Allan V. Kalueff

Physiology and Biophysics

Scientific Research Institute of Neuroscience and Medicine
Novosibirsk State University
Southwest University
Ministry of Healthcare of Russian Federation
St. Petersburg State University
Western Caspian University
Universidade de Passo Fundo
International Zebrafish Neuroscience Research Consortium (ZNRC)
International Stress and Behavior Society (ISBS)
Universidade Federal de Ciências da Saúde de Porto Alegre
University of Oxford
Sechenov First Moscow State Medical University
Institute of General Pathology and Pathophysiology RAMS
University of Toronto
Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences
Xi'an Jiaotong-Liverpool University

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

Abstract

Encoding a key ‘hub’ scaffolding protein, the ‘Disrupted-In-Schizophrenia-1’ (DISC1) gene has been strongly implicated in brain development and functions. Genetic variance in this gene is associated with major neuropsychiatric disorders, including schizophrenia, bipolar disorder, and major depression. DISC1 is abundantly expressed in the brain of humans and various model organisms. Here, we discuss currently available animal models of DISC1-related brain deficits and their clinical relevance. We focus on evolutionarily conserved (shared) mechanisms and species-specific phenotypes, especially in newly developed zebrafish (Danio rerio) models, to better understand the uniquely complex role of DISC1 in the molecular pathogenesis of neurobehavioral abnormalities relevant to human neuropsychiatric disorders.

Original language	English
Article number	43162
Journal	Journal of Integrative Neuroscience
Volume	24
Issue number	9
DOIs	https://doi.org/10.31083/JIN43162
State	Published - Sep 1 2025

Keywords

DISC1
animal models
behavior
neurogenesis
neuropsychiatric disorders
zebrafish

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10.31083/JIN43162

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Volgin, A. D., Cheresiz, S. V., Chizhova, N. D., Smirnova, K. V., Doroshkov, A. V., Galstya, D. S., de Abreu, M. S., Strekalova, T., Lipina, T., Pletnikov, M., Yang, L., Wei Lim, L., Stewart, A. M., Amstislavskaya, T. G., & Kalueff, A. V. (2025). Review Rethinking the Role of DISC1 in CNS Function: Translational Cross-Taxon Insights From Rodent and Zebrafish Models. Journal of Integrative Neuroscience, 24(9), Article 43162. https://doi.org/10.31083/JIN43162

@article{71780729a9c246e58a80ee8732afa26a,

title = "Review Rethinking the Role of DISC1 in CNS Function: Translational Cross-Taxon Insights From Rodent and Zebrafish Models",

abstract = "Encoding a key {\textquoteleft}hub{\textquoteright} scaffolding protein, the {\textquoteleft}Disrupted-In-Schizophrenia-1{\textquoteright} (DISC1) gene has been strongly implicated in brain development and functions. Genetic variance in this gene is associated with major neuropsychiatric disorders, including schizophrenia, bipolar disorder, and major depression. DISC1 is abundantly expressed in the brain of humans and various model organisms. Here, we discuss currently available animal models of DISC1-related brain deficits and their clinical relevance. We focus on evolutionarily conserved (shared) mechanisms and species-specific phenotypes, especially in newly developed zebrafish (Danio rerio) models, to better understand the uniquely complex role of DISC1 in the molecular pathogenesis of neurobehavioral abnormalities relevant to human neuropsychiatric disorders.",

keywords = "DISC1, animal models, behavior, neurogenesis, neuropsychiatric disorders, zebrafish",

author = "Volgin, \{Andrey D.\} and Cheresiz, \{Sergey V.\} and Chizhova, \{Nadezhda D.\} and Smirnova, \{Kristina V.\} and Doroshkov, \{Alexey V.\} and Galstya, \{David S.\} and \{de Abreu\}, \{Murilo S.\} and Tatyana Strekalova and Tatiana Lipina and Mikhail Pletnikov and Longen Yang and \{Wei Lim\}, Lee and Stewart, \{Adam Michael\} and Amstislavskaya, \{Tamara G.\} and Kalueff, \{Allan V.\}",

note = "Publisher Copyright: {\textcopyright} 2025 The Author(s). Published by IMR Press.",

year = "2025",

month = sep,

day = "1",

doi = "10.31083/JIN43162",

language = "English",

volume = "24",

journal = "Journal of Integrative Neuroscience",

issn = "0219-6352",

publisher = "IMR Press Limited",

number = "9",

}

Volgin, AD, Cheresiz, SV, Chizhova, ND, Smirnova, KV, Doroshkov, AV, Galstya, DS, de Abreu, MS, Strekalova, T, Lipina, T, Pletnikov, M, Yang, L, Wei Lim, L, Stewart, AM, Amstislavskaya, TG & Kalueff, AV 2025, 'Review Rethinking the Role of DISC1 in CNS Function: Translational Cross-Taxon Insights From Rodent and Zebrafish Models', Journal of Integrative Neuroscience, vol. 24, no. 9, 43162. https://doi.org/10.31083/JIN43162

TY - JOUR

T1 - Review Rethinking the Role of DISC1 in CNS Function

T2 - Translational Cross-Taxon Insights From Rodent and Zebrafish Models

AU - Volgin, Andrey D.

AU - Cheresiz, Sergey V.

AU - Chizhova, Nadezhda D.

AU - Smirnova, Kristina V.

AU - Doroshkov, Alexey V.

AU - Galstya, David S.

AU - de Abreu, Murilo S.

AU - Strekalova, Tatyana

AU - Lipina, Tatiana

AU - Pletnikov, Mikhail

AU - Yang, Longen

AU - Wei Lim, Lee

AU - Stewart, Adam Michael

AU - Amstislavskaya, Tamara G.

AU - Kalueff, Allan V.

PY - 2025/9/1

Y1 - 2025/9/1

N2 - Encoding a key ‘hub’ scaffolding protein, the ‘Disrupted-In-Schizophrenia-1’ (DISC1) gene has been strongly implicated in brain development and functions. Genetic variance in this gene is associated with major neuropsychiatric disorders, including schizophrenia, bipolar disorder, and major depression. DISC1 is abundantly expressed in the brain of humans and various model organisms. Here, we discuss currently available animal models of DISC1-related brain deficits and their clinical relevance. We focus on evolutionarily conserved (shared) mechanisms and species-specific phenotypes, especially in newly developed zebrafish (Danio rerio) models, to better understand the uniquely complex role of DISC1 in the molecular pathogenesis of neurobehavioral abnormalities relevant to human neuropsychiatric disorders.

AB - Encoding a key ‘hub’ scaffolding protein, the ‘Disrupted-In-Schizophrenia-1’ (DISC1) gene has been strongly implicated in brain development and functions. Genetic variance in this gene is associated with major neuropsychiatric disorders, including schizophrenia, bipolar disorder, and major depression. DISC1 is abundantly expressed in the brain of humans and various model organisms. Here, we discuss currently available animal models of DISC1-related brain deficits and their clinical relevance. We focus on evolutionarily conserved (shared) mechanisms and species-specific phenotypes, especially in newly developed zebrafish (Danio rerio) models, to better understand the uniquely complex role of DISC1 in the molecular pathogenesis of neurobehavioral abnormalities relevant to human neuropsychiatric disorders.

KW - DISC1

KW - animal models

KW - behavior

KW - neurogenesis

KW - neuropsychiatric disorders

KW - zebrafish

UR - https://www.scopus.com/pages/publications/105018398404

U2 - 10.31083/JIN43162

DO - 10.31083/JIN43162

M3 - Review article

C2 - 41074414

AN - SCOPUS:105018398404

SN - 0219-6352

VL - 24

JO - Journal of Integrative Neuroscience

JF - Journal of Integrative Neuroscience

IS - 9

M1 - 43162

ER -

Review Rethinking the Role of DISC1 in CNS Function: Translational Cross-Taxon Insights From Rodent and Zebrafish Models

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Keywords

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