Review: R28 retinal precursor cells: The first 20 years

Gail M. Seigel

Review: R28 retinal precursor cells: The first 20 years

Gail M. Seigel

Communicative Disorders and Sciences

Research output: Contribution to journal › Article › peer-review

78 Scopus citations

Abstract

The R28 retinal precursor cell line was established 20 years ago, originating from a postnatal day 6 rat retinal culture immortalized with the 12S E1A (NP-040507) gene of the adenovirus in a replication-incompetent viral vector. Since that time, R28 cells have been characterized and used for a variety of in vitro and in vivo studies of retinal cell behavior, including differentiation, neuroprotection, cytotoxicity, and light stimulation, as well as retinal gene expression and neuronal function. While no cell culture is equivalent to the intact eye, R28 cells continue to provide an important experimental system for the study of many retinal processes.

Original language	English
Pages (from-to)	301-306
Number of pages	6
Journal	Molecular Vision
Volume	20
State	Published - Mar 14 2014

Cite this

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abstract = "The R28 retinal precursor cell line was established 20 years ago, originating from a postnatal day 6 rat retinal culture immortalized with the 12S E1A (NP-040507) gene of the adenovirus in a replication-incompetent viral vector. Since that time, R28 cells have been characterized and used for a variety of in vitro and in vivo studies of retinal cell behavior, including differentiation, neuroprotection, cytotoxicity, and light stimulation, as well as retinal gene expression and neuronal function. While no cell culture is equivalent to the intact eye, R28 cells continue to provide an important experimental system for the study of many retinal processes.",

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Review: R28 retinal precursor cells: The first 20 years

Abstract

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