Regulation of the interferon regulatory factor-8 (IRF-8) tumor suppressor gene by the signal transducer and activator of transcription 5 (STAT5) transcription factor in chronic myeloid leukemia

Jeremy D. Waight; Debarati Banik; Elizabeth A. Griffiths; Michael J. Nemeth; Scott I. Abrams

doi:10.1074/jbc.M113.544320

Regulation of the interferon regulatory factor-8 (IRF-8) tumor suppressor gene by the signal transducer and activator of transcription 5 (STAT5) transcription factor in chronic myeloid leukemia

Jeremy D. Waight
, Debarati Banik
, Elizabeth A. Griffiths
, Michael J. Nemeth
, Scott I. Abrams

Office of Research Compliance

Roswell Park Cancer Institute

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Background: The IRF-8 tumor suppressor gene is down-regulated in chronic myeloid leukemia (CML). Results: The STAT5 transcription factor regulates IRF-8 expression in CML cells. Conclusion: In CML, oncogene-mediated activation of STAT5 is responsible for suppressing the IRF-8 gene. Significance: An oncogene driven STAT5-IRF-8 signaling axis regulates CML biology and may be implicated in other types of myeloid malignanices.

Original language	English
Pages (from-to)	15642-15652
Number of pages	11
Journal	Journal of Biological Chemistry
Volume	289
Issue number	22
DOIs	https://doi.org/10.1074/jbc.M113.544320
State	Published - May 30 2014

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10.1074/jbc.M113.544320

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Waight, J. D., Banik, D., Griffiths, E. A., Nemeth, M. J., & Abrams, S. I. (2014). Regulation of the interferon regulatory factor-8 (IRF-8) tumor suppressor gene by the signal transducer and activator of transcription 5 (STAT5) transcription factor in chronic myeloid leukemia. Journal of Biological Chemistry, 289(22), 15642-15652. https://doi.org/10.1074/jbc.M113.544320

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title = "Regulation of the interferon regulatory factor-8 (IRF-8) tumor suppressor gene by the signal transducer and activator of transcription 5 (STAT5) transcription factor in chronic myeloid leukemia",

abstract = "Background: The IRF-8 tumor suppressor gene is down-regulated in chronic myeloid leukemia (CML). Results: The STAT5 transcription factor regulates IRF-8 expression in CML cells. Conclusion: In CML, oncogene-mediated activation of STAT5 is responsible for suppressing the IRF-8 gene. Significance: An oncogene driven STAT5-IRF-8 signaling axis regulates CML biology and may be implicated in other types of myeloid malignanices.",

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Waight, JD, Banik, D, Griffiths, EA, Nemeth, MJ & Abrams, SI 2014, 'Regulation of the interferon regulatory factor-8 (IRF-8) tumor suppressor gene by the signal transducer and activator of transcription 5 (STAT5) transcription factor in chronic myeloid leukemia', Journal of Biological Chemistry, vol. 289, no. 22, pp. 15642-15652. https://doi.org/10.1074/jbc.M113.544320

Regulation of the interferon regulatory factor-8 (IRF-8) tumor suppressor gene by the signal transducer and activator of transcription 5 (STAT5) transcription factor in chronic myeloid leukemia. / Waight, Jeremy D.; Banik, Debarati; Griffiths, Elizabeth A. et al.
In: Journal of Biological Chemistry, Vol. 289, No. 22, 30.05.2014, p. 15642-15652.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Regulation of the interferon regulatory factor-8 (IRF-8) tumor suppressor gene by the signal transducer and activator of transcription 5 (STAT5) transcription factor in chronic myeloid leukemia

AU - Waight, Jeremy D.

AU - Banik, Debarati

AU - Griffiths, Elizabeth A.

AU - Nemeth, Michael J.

AU - Abrams, Scott I.

PY - 2014/5/30

Y1 - 2014/5/30

N2 - Background: The IRF-8 tumor suppressor gene is down-regulated in chronic myeloid leukemia (CML). Results: The STAT5 transcription factor regulates IRF-8 expression in CML cells. Conclusion: In CML, oncogene-mediated activation of STAT5 is responsible for suppressing the IRF-8 gene. Significance: An oncogene driven STAT5-IRF-8 signaling axis regulates CML biology and may be implicated in other types of myeloid malignanices.

AB - Background: The IRF-8 tumor suppressor gene is down-regulated in chronic myeloid leukemia (CML). Results: The STAT5 transcription factor regulates IRF-8 expression in CML cells. Conclusion: In CML, oncogene-mediated activation of STAT5 is responsible for suppressing the IRF-8 gene. Significance: An oncogene driven STAT5-IRF-8 signaling axis regulates CML biology and may be implicated in other types of myeloid malignanices.

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JF - Journal of Biological Chemistry

IS - 22

ER -

Regulation of the interferon regulatory factor-8 (IRF-8) tumor suppressor gene by the signal transducer and activator of transcription 5 (STAT5) transcription factor in chronic myeloid leukemia

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