TY - JOUR
T1 - Regular Physical Inactivity and Ovarian Cancer Risk in the Ovarian Cancer in Women of African Ancestry Consortium
AU - Lima, Sarah M.
AU - Minlikeeva, Albina N.
AU - Johnson, Courtney E.
AU - Guertin, Kristin A.
AU - Bandera, Elisa V.
AU - Zheng, Wei
AU - Bethea, Traci N.
AU - Petrick, Jessica L.
AU - Joslin, Charlotte E.
AU - Myers, Evan R.
AU - Harris, Holly R.
AU - Peres, Lauren C.
AU - Setiawan, Veronica Wendy
AU - Wu, Anna H.
AU - Rosenberg, Lynn
AU - Schildkraut, Joellen M.
AU - Ochs-Balcom, Heather M.
N1 - Publisher Copyright:
©2025 American Association for Cancer Research.
PY - 2025/12/1
Y1 - 2025/12/1
N2 - BACKGROUND: Regular physical inactivity may increase ovarian cancer risk, but few studies have investigated whether this association is similar among Black and White women. METHODS: In a pooled nested case-control study within the Ovarian Cancer in Women of African Ancestry consortium, logistic regression models evaluated regular recreational physical inactivity with risk of epithelial ovarian cancer among Black (223 cases; 1,472 controls) and White women (985 cases; 6,212 controls) enrolled in four cohort studies. Models were further stratified by histologic type. RESULTS: Regular physical inactivity was not associated with the risk of overall ovarian cancer among Black [OR = 1.16; 95% confidence interval (CI), 0.83-1.61] or White women (OR = 1.03; 95% CI, 0.87-1.23). We did not detect associations according to histologic type. CONCLUSIONS: Physical inactivity was not associated with ovarian cancer among Black or White women in a consortium of cohort studies. IMPACT: These results are counter to case-control-based studies and emphasize the complexity of investigating physical activity prospectively.
AB - BACKGROUND: Regular physical inactivity may increase ovarian cancer risk, but few studies have investigated whether this association is similar among Black and White women. METHODS: In a pooled nested case-control study within the Ovarian Cancer in Women of African Ancestry consortium, logistic regression models evaluated regular recreational physical inactivity with risk of epithelial ovarian cancer among Black (223 cases; 1,472 controls) and White women (985 cases; 6,212 controls) enrolled in four cohort studies. Models were further stratified by histologic type. RESULTS: Regular physical inactivity was not associated with the risk of overall ovarian cancer among Black [OR = 1.16; 95% confidence interval (CI), 0.83-1.61] or White women (OR = 1.03; 95% CI, 0.87-1.23). We did not detect associations according to histologic type. CONCLUSIONS: Physical inactivity was not associated with ovarian cancer among Black or White women in a consortium of cohort studies. IMPACT: These results are counter to case-control-based studies and emphasize the complexity of investigating physical activity prospectively.
UR - https://www.scopus.com/pages/publications/105018647015
U2 - 10.1158/1055-9965.EPI-25-1160
DO - 10.1158/1055-9965.EPI-25-1160
M3 - Article
C2 - 40956289
AN - SCOPUS:105018647015
SN - 1055-9965
VL - 34
SP - 2302
EP - 2305
JO - Cancer Epidemiology Biomarkers and Prevention
JF - Cancer Epidemiology Biomarkers and Prevention
IS - 12
ER -