Reexamination of the dose-response relationship for induction of the hepatic monooxygenase system by 2,3,7,8-TCDD

James R. Olson; Steven I. Gutman; Emily S. Shen

doi:10.1016/0045-6535(89)90142-2

Reexamination of the dose-response relationship for induction of the hepatic monooxygenase system by 2,3,7,8-TCDD

James R. Olson
, Steven I. Gutman
, Emily S. Shen

Department of Epidemiology and Environmental Health

SUNY Buffalo

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The induction of the cytochrome-P-450-dependent monooxygenase system is one of the most sensitive responses associated with exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD). The object of this study was to investigate the induction of the hepatic monooxygenase system over a wide range of doses of 2,3,7,8-TCDD, including those associated with acute toxicity.

Original language	English
Pages (from-to)	363-370
Number of pages	8
Journal	Chemosphere
Volume	18
Issue number	1-6
DOIs	https://doi.org/10.1016/0045-6535(89)90142-2
State	Published - 1989

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title = "Reexamination of the dose-response relationship for induction of the hepatic monooxygenase system by 2,3,7,8-TCDD",

abstract = "The induction of the cytochrome-P-450-dependent monooxygenase system is one of the most sensitive responses associated with exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD). The object of this study was to investigate the induction of the hepatic monooxygenase system over a wide range of doses of 2,3,7,8-TCDD, including those associated with acute toxicity.",

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journal = "Chemosphere",

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AU - Olson, James R.

AU - Gutman, Steven I.

AU - Shen, Emily S.

PY - 1989

Y1 - 1989

N2 - The induction of the cytochrome-P-450-dependent monooxygenase system is one of the most sensitive responses associated with exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD). The object of this study was to investigate the induction of the hepatic monooxygenase system over a wide range of doses of 2,3,7,8-TCDD, including those associated with acute toxicity.

AB - The induction of the cytochrome-P-450-dependent monooxygenase system is one of the most sensitive responses associated with exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD). The object of this study was to investigate the induction of the hepatic monooxygenase system over a wide range of doses of 2,3,7,8-TCDD, including those associated with acute toxicity.

UR - https://www.scopus.com/pages/publications/0024405733

U2 - 10.1016/0045-6535(89)90142-2

DO - 10.1016/0045-6535(89)90142-2

M3 - Article

AN - SCOPUS:0024405733

SN - 0045-6535

VL - 18

SP - 363

EP - 370

JO - Chemosphere

JF - Chemosphere

IS - 1-6

ER -

Reexamination of the dose-response relationship for induction of the hepatic monooxygenase system by 2,3,7,8-TCDD

Abstract

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