Recombinant factor VIIA, its clinical properties, and the tissue factor pathway of coagulation

Timothy J. Bosinski; Ali A. El Solh

doi:10.2174/138955706778560201

Recombinant factor VIIA, its clinical properties, and the tissue factor pathway of coagulation

Timothy J. Bosinski
, Ali A. El Solh

Medicine

Novo Nordisk Foundation

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Recombinant factor VIIa (rFVIIa) is a synthetic coagulation protease that is structurally similar to human-derived plasma FVIIa. Pharmacologic doses of rFVIIa have been shown to enhance thrombin generation and assist in forming stable fibrin plugs at the site of injury. Recombinant factor VIIa appears to emerge as a valuable treatment alternative for the treatment of bleeding episodes and for achieving hemostasis post surgery in those with bleeding disorders.

Original language	English
Pages (from-to)	1111-1117
Number of pages	7
Journal	Mini-Reviews in Medicinal Chemistry
Volume	6
Issue number	10
DOIs	https://doi.org/10.2174/138955706778560201
State	Published - Oct 2006

Keywords

Coagulation
Hemostasis
Recombinant factor VIIa
Tissue factor

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10.2174/138955706778560201

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abstract = "Recombinant factor VIIa (rFVIIa) is a synthetic coagulation protease that is structurally similar to human-derived plasma FVIIa. Pharmacologic doses of rFVIIa have been shown to enhance thrombin generation and assist in forming stable fibrin plugs at the site of injury. Recombinant factor VIIa appears to emerge as a valuable treatment alternative for the treatment of bleeding episodes and for achieving hemostasis post surgery in those with bleeding disorders.",

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KW - Hemostasis

KW - Recombinant factor VIIa

KW - Tissue factor

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Recombinant factor VIIA, its clinical properties, and the tissue factor pathway of coagulation

Abstract

Keywords

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