Recognition of thymine in DNA bulges by a Zn(ii) macrocyclic complex

Imee Marie A. Del Mundo; Matthew A. Fountain; Janet R. Morrow

doi:10.1039/c1cc12074c

Recognition of thymine in DNA bulges by a Zn(ii) macrocyclic complex

Imee Marie A. Del Mundo
, Matthew A. Fountain
, Janet R. Morrow

Chemistry

SUNY Buffalo
State University of New York at Fredonia

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

A Zn(ii) macrocyclic complex with appended quinoline is a bifunctional recognition agent that uses both the Zn(ii) center and the pendent aromatic group to bind to thymine in bulges with good selectivity over DNA containing G, C or A bulges. Spectroscopic studies show that the stem containing the bulge stays largely intact in a DNA hairpin with the Zn(ii) complex bound to the thymine bulge.

Original language	English
Pages (from-to)	8566-8568
Number of pages	3
Journal	Chemical Communications
Volume	47
Issue number	30
DOIs	https://doi.org/10.1039/c1cc12074c
State	Published - Aug 14 2011

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title = "Recognition of thymine in DNA bulges by a Zn(ii) macrocyclic complex",

abstract = "A Zn(ii) macrocyclic complex with appended quinoline is a bifunctional recognition agent that uses both the Zn(ii) center and the pendent aromatic group to bind to thymine in bulges with good selectivity over DNA containing G, C or A bulges. Spectroscopic studies show that the stem containing the bulge stays largely intact in a DNA hairpin with the Zn(ii) complex bound to the thymine bulge.",

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AU - Fountain, Matthew A.

AU - Morrow, Janet R.

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AB - A Zn(ii) macrocyclic complex with appended quinoline is a bifunctional recognition agent that uses both the Zn(ii) center and the pendent aromatic group to bind to thymine in bulges with good selectivity over DNA containing G, C or A bulges. Spectroscopic studies show that the stem containing the bulge stays largely intact in a DNA hairpin with the Zn(ii) complex bound to the thymine bulge.

UR - https://www.scopus.com/pages/publications/79960526435

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DO - 10.1039/c1cc12074c

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VL - 47

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JO - Chemical Communications

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ER -

Recognition of thymine in DNA bulges by a Zn(ii) macrocyclic complex

Abstract

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