Recognition of immunoglobulin A1 by oral actinomyces and streptococcal lectins

S. Ruhl; A. L. Sandberg; M. F. Cole; J. O. Cisar

doi:10.1128/iai.64.12.5421-5424.1996

Recognition of immunoglobulin A1 by oral actinomyces and streptococcal lectins

S. Ruhl
, A. L. Sandberg
, M. F. Cole
, J. O. Cisar

Department of Oral Biology

National Institutes of Health
Georgetown University

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

Actinomyces naeslundii and Streptococcus gordonii, oral bacteria that possess Gal/GalNAc- and sialic acid-reactive lectins, respectively, were adherent to immobilized secretory immunoglobulin A (IgA) and two IgA1 myeloma proteins but not to two IgA2 myeloma proteins. Apparently, O-linked oligosaccharides at the hinge region of the IgA1 heavy chain are receptors for lectin-mediated adhesion of these bacteria.

Original language	English
Pages (from-to)	5421-5424
Number of pages	4
Journal	Infection and Immunity
Volume	64
Issue number	12
DOIs	https://doi.org/10.1128/iai.64.12.5421-5424.1996
State	Published - 1996

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10.1128/iai.64.12.5421-5424.1996

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title = "Recognition of immunoglobulin A1 by oral actinomyces and streptococcal lectins",

abstract = "Actinomyces naeslundii and Streptococcus gordonii, oral bacteria that possess Gal/GalNAc- and sialic acid-reactive lectins, respectively, were adherent to immobilized secretory immunoglobulin A (IgA) and two IgA1 myeloma proteins but not to two IgA2 myeloma proteins. Apparently, O-linked oligosaccharides at the hinge region of the IgA1 heavy chain are receptors for lectin-mediated adhesion of these bacteria.",

author = "S. Ruhl and Sandberg, \{A. L.\} and Cole, \{M. F.\} and Cisar, \{J. O.\}",

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AU - Ruhl, S.

AU - Sandberg, A. L.

AU - Cole, M. F.

AU - Cisar, J. O.

PY - 1996

Y1 - 1996

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AB - Actinomyces naeslundii and Streptococcus gordonii, oral bacteria that possess Gal/GalNAc- and sialic acid-reactive lectins, respectively, were adherent to immobilized secretory immunoglobulin A (IgA) and two IgA1 myeloma proteins but not to two IgA2 myeloma proteins. Apparently, O-linked oligosaccharides at the hinge region of the IgA1 heavy chain are receptors for lectin-mediated adhesion of these bacteria.

UR - https://www.scopus.com/pages/publications/0029810199

U2 - 10.1128/iai.64.12.5421-5424.1996

DO - 10.1128/iai.64.12.5421-5424.1996

M3 - Article

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AN - SCOPUS:0029810199

SN - 0019-9567

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SP - 5421

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JO - Infection and Immunity

JF - Infection and Immunity

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ER -

Recognition of immunoglobulin A1 by oral actinomyces and streptococcal lectins

Abstract

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