Abstract
Photo-cross-linkers are invaluable tools for identifying drug targets and off-targets as well as probing the binding sites in medicinal chemistry and chemical biology. In this review, we summarize recent development of the ligand-based and genetically encoded photo-cross-linkers and their use in biological system. In particular, we highlight our discovery of 2-aryl-5-carboxytetrazole (ACT) as a novel class of photo-cross-linkers and their successful applications in drug target identification as well as identifying transient protein–protein interaction complexes in mammalian cells.
| Original language | English |
|---|---|
| Pages (from-to) | 758-763 |
| Number of pages | 6 |
| Journal | Chimia |
| Volume | 72 |
| Issue number | 11 |
| DOIs | |
| State | Published - 2018 |
Keywords
- Genetic encoding
- Photo-affinity probe
- Photo-cross-linker
- Protein–protein interaction
- Target identification
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