Reaction of Saturated (5α- and 5β-) 19-Hydroxy Steroids with Mixed Phosphorus and Halogen Containing Reagents

Enzo Santaniello; Eliahu Caspi; William L. Duax; Charles M. Weeks

doi:10.1021/jo00423a019

Reaction of Saturated (5α- and 5β-) 19-Hydroxy Steroids with Mixed Phosphorus and Halogen Containing Reagents

Enzo Santaniello
, Eliahu Caspi
, William L. Duax
, Charles M. Weeks

Department of Structural Biology

University of Massachusetts Medical School
Hauptman-Woodward Medical Research Institute, Inc.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Attempts to convert saturated (5α- and 5β-) 19-hydroxylated steroids to 19-halogenated analogues with the use of mixed phosphorus and halogen containing reagents are described. The 19-halogenated analogues were not obtained, but certain transformations in the 5a series and rearrangements in the 5β series were noted and are discussed.

Original language	English
Pages (from-to)	482-486
Number of pages	5
Journal	Journal of Organic Chemistry
Volume	42
Issue number	3
DOIs	https://doi.org/10.1021/jo00423a019
State	Published - 1977

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@article{0d5fadaef19b4bd7a9800665af8fb6cc,

title = "Reaction of Saturated (5α- and 5β-) 19-Hydroxy Steroids with Mixed Phosphorus and Halogen Containing Reagents",

abstract = "Attempts to convert saturated (5α- and 5β-) 19-hydroxylated steroids to 19-halogenated analogues with the use of mixed phosphorus and halogen containing reagents are described. The 19-halogenated analogues were not obtained, but certain transformations in the 5a series and rearrangements in the 5β series were noted and are discussed.",

author = "Enzo Santaniello and Eliahu Caspi and Duax, \{William L.\} and Weeks, \{Charles M.\}",

year = "1977",

doi = "10.1021/jo00423a019",

language = "English",

volume = "42",

pages = "482--486",

journal = "Journal of Organic Chemistry",

issn = "0022-3263",

publisher = "American Chemical Society",

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T1 - Reaction of Saturated (5α- and 5β-) 19-Hydroxy Steroids with Mixed Phosphorus and Halogen Containing Reagents

AU - Santaniello, Enzo

AU - Caspi, Eliahu

AU - Duax, William L.

AU - Weeks, Charles M.

PY - 1977

Y1 - 1977

N2 - Attempts to convert saturated (5α- and 5β-) 19-hydroxylated steroids to 19-halogenated analogues with the use of mixed phosphorus and halogen containing reagents are described. The 19-halogenated analogues were not obtained, but certain transformations in the 5a series and rearrangements in the 5β series were noted and are discussed.

AB - Attempts to convert saturated (5α- and 5β-) 19-hydroxylated steroids to 19-halogenated analogues with the use of mixed phosphorus and halogen containing reagents are described. The 19-halogenated analogues were not obtained, but certain transformations in the 5a series and rearrangements in the 5β series were noted and are discussed.

UR - https://www.scopus.com/pages/publications/0017766653

U2 - 10.1021/jo00423a019

DO - 10.1021/jo00423a019

M3 - Article

C2 - 833699

AN - SCOPUS:0017766653

SN - 0022-3263

VL - 42

SP - 482

EP - 486

JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

IS - 3

ER -

Reaction of Saturated (5α- and 5β-) 19-Hydroxy Steroids with Mixed Phosphorus and Halogen Containing Reagents

Abstract

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