Radiopharmaceutical for differential diagnosis of tuberculoma: Synthesis of 2-[11C]cyano-isonicotinic acid hydrazide

C. W. Somawardhana; Munawwar Sajjad; Richard M. Lambrecht

doi:10.1016/0883-2889(91)90162-T

Radiopharmaceutical for differential diagnosis of tuberculoma: Synthesis of 2-[¹¹C]cyano-isonicotinic acid hydrazide

C. W. Somawardhana
, Munawwar Sajjad
, Richard M. Lambrecht

Radiology

King Faisal Specialist Hospital and Research Centre

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

The radiochemical synthesis of 2-[¹¹C]cyano-isonicotinic acid hydrazide was accomplished. Carbon-11 labelled cyano-group was introduced at the 2-position of the pyridine ring of 1-methoxy-4-methoxycarbonyl pyridinium methyl sulfate via a Reissert-Kaufmann type reaction. The reaction was performed on a solid support (silica gel) to yield no-carrier-added methyl 2-[¹¹C]cyano-isonicotinate in (32.4 ± 12%) (EOB) yield. This method is unique for the incorporation of [¹¹C]HCN to base sensitive substrates. The carbon-11 labelled methyl ester was treated with hydrazine hydrate to obtain 2-[¹¹C]cyano-isonicotinic acid hydrazide. The final radiochemical yield was 10% (EOB) and the synthesis time was approximately 35 min.

Original language	English
Pages (from-to)	559-562
Number of pages	4
Journal	International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes
Volume	42
Issue number	6
DOIs	https://doi.org/10.1016/0883-2889(91)90162-T
State	Published - 1991

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@article{d772bddb954342ddbd07fe8dc54aad29,

title = "Radiopharmaceutical for differential diagnosis of tuberculoma: Synthesis of 2-[11C]cyano-isonicotinic acid hydrazide",

abstract = "The radiochemical synthesis of 2-[11C]cyano-isonicotinic acid hydrazide was accomplished. Carbon-11 labelled cyano-group was introduced at the 2-position of the pyridine ring of 1-methoxy-4-methoxycarbonyl pyridinium methyl sulfate via a Reissert-Kaufmann type reaction. The reaction was performed on a solid support (silica gel) to yield no-carrier-added methyl 2-[11C]cyano-isonicotinate in (32.4 ± 12\%) (EOB) yield. This method is unique for the incorporation of [11C]HCN to base sensitive substrates. The carbon-11 labelled methyl ester was treated with hydrazine hydrate to obtain 2-[11C]cyano-isonicotinic acid hydrazide. The final radiochemical yield was 10\% (EOB) and the synthesis time was approximately 35 min.",

author = "Somawardhana, \{C. W.\} and Munawwar Sajjad and Lambrecht, \{Richard M.\}",

year = "1991",

doi = "10.1016/0883-2889(91)90162-T",

language = "English",

volume = "42",

pages = "559--562",

journal = "International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes",

issn = "0883-2889",

publisher = "Pergamon Press Ltd.",

number = "6",

}

Radiopharmaceutical for differential diagnosis of tuberculoma: Synthesis of 2-[¹¹C]cyano-isonicotinic acid hydrazide. / Somawardhana, C. W.; Sajjad, Munawwar; Lambrecht, Richard M.
In: International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes, Vol. 42, No. 6, 1991, p. 559-562.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Radiopharmaceutical for differential diagnosis of tuberculoma

T2 - Synthesis of 2-[11C]cyano-isonicotinic acid hydrazide

AU - Somawardhana, C. W.

AU - Sajjad, Munawwar

AU - Lambrecht, Richard M.

PY - 1991

Y1 - 1991

N2 - The radiochemical synthesis of 2-[11C]cyano-isonicotinic acid hydrazide was accomplished. Carbon-11 labelled cyano-group was introduced at the 2-position of the pyridine ring of 1-methoxy-4-methoxycarbonyl pyridinium methyl sulfate via a Reissert-Kaufmann type reaction. The reaction was performed on a solid support (silica gel) to yield no-carrier-added methyl 2-[11C]cyano-isonicotinate in (32.4 ± 12%) (EOB) yield. This method is unique for the incorporation of [11C]HCN to base sensitive substrates. The carbon-11 labelled methyl ester was treated with hydrazine hydrate to obtain 2-[11C]cyano-isonicotinic acid hydrazide. The final radiochemical yield was 10% (EOB) and the synthesis time was approximately 35 min.

AB - The radiochemical synthesis of 2-[11C]cyano-isonicotinic acid hydrazide was accomplished. Carbon-11 labelled cyano-group was introduced at the 2-position of the pyridine ring of 1-methoxy-4-methoxycarbonyl pyridinium methyl sulfate via a Reissert-Kaufmann type reaction. The reaction was performed on a solid support (silica gel) to yield no-carrier-added methyl 2-[11C]cyano-isonicotinate in (32.4 ± 12%) (EOB) yield. This method is unique for the incorporation of [11C]HCN to base sensitive substrates. The carbon-11 labelled methyl ester was treated with hydrazine hydrate to obtain 2-[11C]cyano-isonicotinic acid hydrazide. The final radiochemical yield was 10% (EOB) and the synthesis time was approximately 35 min.

UR - https://www.scopus.com/pages/publications/0025753942

U2 - 10.1016/0883-2889(91)90162-T

DO - 10.1016/0883-2889(91)90162-T

M3 - Article

AN - SCOPUS:0025753942

SN - 0883-2889

VL - 42

SP - 559

EP - 562

JO - International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes

JF - International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes

IS - 6

ER -

Radiopharmaceutical for differential diagnosis of tuberculoma: Synthesis of 2-[¹¹C]cyano-isonicotinic acid hydrazide

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