Radiation induced brain edema in primates, studied with sequential brain cat scanning and histopathology. Protective effect of sodium meclofenamate. A preliminary report

J. Halpern; S. P. Kishel; J. Park; Y. Tsukada; R. J. Johnson; J. L. Ambrus

Radiation induced brain edema in primates, studied with sequential brain cat scanning and histopathology. Protective effect of sodium meclofenamate. A preliminary report

J. Halpern
, S. P. Kishel
, J. Park
, Y. Tsukada
, R. J. Johnson
, J. L. Ambrus

Medicine

Roswell Park Cancer Institute

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Four Cynomologous monkeys (Mecaca fascicularis) received 2000 Rad whole brain irradiation. One remained untreated and exhibited loss of hair, facial edema, brain edema and hydrocephalus. There was loss of alertness and motor activity. One was scheduled to be treated with phenobarbital, but died 24 hours after irradiation. One animal received 2 mg/kg dexamethasone I.M. daily. It died two weeks after irradiation apparently due to treatment related infection. One animal received 20 mg/kg sodium meclofenamate (Meclomen) orally daily. This animal showed no brain edema and only minimal hydrocephalus, delayed and incomplete hair loss and no facial edema. Further studies of this treatment appear to be justified.

Original language	English
Pages (from-to)	463-470
Number of pages	8
Journal	Research Communications in Chemical Pathology and Pharmacology
Volume	45
Issue number	3
State	Published - 1984

Cite this

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title = "Radiation induced brain edema in primates, studied with sequential brain cat scanning and histopathology. Protective effect of sodium meclofenamate. A preliminary report",

abstract = "Four Cynomologous monkeys (Mecaca fascicularis) received 2000 Rad whole brain irradiation. One remained untreated and exhibited loss of hair, facial edema, brain edema and hydrocephalus. There was loss of alertness and motor activity. One was scheduled to be treated with phenobarbital, but died 24 hours after irradiation. One animal received 2 mg/kg dexamethasone I.M. daily. It died two weeks after irradiation apparently due to treatment related infection. One animal received 20 mg/kg sodium meclofenamate (Meclomen) orally daily. This animal showed no brain edema and only minimal hydrocephalus, delayed and incomplete hair loss and no facial edema. Further studies of this treatment appear to be justified.",

author = "J. Halpern and Kishel, \{S. P.\} and J. Park and Y. Tsukada and Johnson, \{R. J.\} and Ambrus, \{J. L.\}",

year = "1984",

language = "English",

volume = "45",

pages = "463--470",

journal = "Research Communications in Chemical Pathology and Pharmacology",

issn = "0034-5164",

publisher = "PJD Publications Ltd",

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}

Radiation induced brain edema in primates, studied with sequential brain cat scanning and histopathology. Protective effect of sodium meclofenamate. A preliminary report. / Halpern, J.; Kishel, S. P.; Park, J. et al.
In: Research Communications in Chemical Pathology and Pharmacology, Vol. 45, No. 3, 1984, p. 463-470.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Radiation induced brain edema in primates, studied with sequential brain cat scanning and histopathology. Protective effect of sodium meclofenamate. A preliminary report

AU - Halpern, J.

AU - Kishel, S. P.

AU - Park, J.

AU - Tsukada, Y.

AU - Johnson, R. J.

AU - Ambrus, J. L.

PY - 1984

Y1 - 1984

N2 - Four Cynomologous monkeys (Mecaca fascicularis) received 2000 Rad whole brain irradiation. One remained untreated and exhibited loss of hair, facial edema, brain edema and hydrocephalus. There was loss of alertness and motor activity. One was scheduled to be treated with phenobarbital, but died 24 hours after irradiation. One animal received 2 mg/kg dexamethasone I.M. daily. It died two weeks after irradiation apparently due to treatment related infection. One animal received 20 mg/kg sodium meclofenamate (Meclomen) orally daily. This animal showed no brain edema and only minimal hydrocephalus, delayed and incomplete hair loss and no facial edema. Further studies of this treatment appear to be justified.

AB - Four Cynomologous monkeys (Mecaca fascicularis) received 2000 Rad whole brain irradiation. One remained untreated and exhibited loss of hair, facial edema, brain edema and hydrocephalus. There was loss of alertness and motor activity. One was scheduled to be treated with phenobarbital, but died 24 hours after irradiation. One animal received 2 mg/kg dexamethasone I.M. daily. It died two weeks after irradiation apparently due to treatment related infection. One animal received 20 mg/kg sodium meclofenamate (Meclomen) orally daily. This animal showed no brain edema and only minimal hydrocephalus, delayed and incomplete hair loss and no facial edema. Further studies of this treatment appear to be justified.

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SN - 0034-5164

VL - 45

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JO - Research Communications in Chemical Pathology and Pharmacology

JF - Research Communications in Chemical Pathology and Pharmacology

IS - 3

ER -

Radiation induced brain edema in primates, studied with sequential brain cat scanning and histopathology. Protective effect of sodium meclofenamate. A preliminary report

Abstract

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