TY - JOUR
T1 - Racial/ethnic differences in the epidemiology of ovarian cancer
T2 - A pooled analysis of 12 case-control studies
AU - On behalf of the African American Cancer Epidemiology Study and the Ovarian Cancer Association Consortium
AU - Australian Ovarian Cancer Study Group
AU - Peres, Lauren C.
AU - Risch, Harvey
AU - Terry, Kathryn L.
AU - MWebb, Penelope
AU - Goodman, Marc T.
AU - Wu, Anna H.
AU - Alberg, Anthony J.
AU - Bandera, Elisa V.
AU - Barnholtz-Sloan, Jill
AU - Bondy, Melissa L.
AU - Cote, Michele L.
AU - Funkhouser, Ellen
AU - Moorman, Patricia G.
AU - Peters, Edward S.
AU - Schwartz, Ann G.
AU - Terry, Paul D.
AU - Manichaikul, Ani
AU - Abbott, Sarah E.
AU - Camacho, Fabian
AU - Jordan, Susan J.
AU - Nagle, Christina M.
AU - Rossing, Mary Anne
AU - Doherty, Jennifer A.
AU - Modugno, Francesmary
AU - Moysich, Kirsten
AU - Ness, Roberta
AU - Berchuck, Andrew
AU - Cook, Linda
AU - Le, Nhu
AU - Brooks-Wilson, Angela
AU - Sieh, Weiva
AU - Whittemore, Alice
AU - McGuire, Valerie
AU - Rothstein, Joseph
AU - Anton-Culver, Hoda
AU - Ziogas, Argyrios
AU - Pearce, Celeste L.
AU - Tseng, Chiuchen
AU - Pike, Malcom
AU - Schildkraut, Joellen M.
N1 - Publisher Copyright:
© The Author 2017; Published by Oxford University Press on behalf of the International Epidemiological Association all rights reserved.
PY - 2018/4
Y1 - 2018/4
N2 - Background: Ovarian cancer incidence differs substantially by race/ethnicity, but the reasons for this are not well understood. Data were pooled from the African American Cancer Epidemiology Study (AACES) and 11 case-control studies in the Ovarian Cancer Association Consortium (OCAC) to examine racial/ethnic differences in epidemiological characteristics with suspected involvement in epithelial ovarian cancer (EOC) aetiology. Methods: We used multivariable logistic regression to estimate associations for 17 reproductive, hormonal and lifestyle characteristics and EOC risk by race/ethnicity among 10 924 women with invasive EOC (8918 Non-Hispanic Whites, 433 Hispanics, 911 Blacks, 662 Asian/Pacific Islanders) and 16 150 controls (13 619 Non-Hispanic Whites, 533 Hispanics, 1233 Blacks, 765 Asian/Pacific Islanders). Likelihood ratio tests were used to evaluate heterogeneity in the risk factor associations by race/ethnicity. Results: We observed statistically significant racial/ethnic heterogeneity for hysterectomy and EOC risk (P=0.008), where the largest odds ratio (OR) was observed in Black women [OR=1.64, 95% confidence interval (CI)=1.34-2.02] compared with other racial/ ethnic groups. Although not statistically significant, the associations for parity, firstdegree family history of ovarian or breast cancer, and endometriosis varied by race/ethnicity. Asian/Pacific Islanders had the greatest magnitude of association for parity (≥3 births: OR=0.38, 95% CI=0.28-0.54), and Black women had the largest ORs for family history (OR=1.77, 95% CI=1.42-2.21) and endometriosis (OR=2.42, 95% CI=1.65- 3.55). Conclusions: Although racial/ethnic heterogeneity was observed for hysterectomy, our findings support the validity of EOC risk factors across all racial/ethnic groups, and further suggest that any racial/ethnic population with a higher prevalence of a modifiable risk factor should be targeted to disseminate information about prevention.
AB - Background: Ovarian cancer incidence differs substantially by race/ethnicity, but the reasons for this are not well understood. Data were pooled from the African American Cancer Epidemiology Study (AACES) and 11 case-control studies in the Ovarian Cancer Association Consortium (OCAC) to examine racial/ethnic differences in epidemiological characteristics with suspected involvement in epithelial ovarian cancer (EOC) aetiology. Methods: We used multivariable logistic regression to estimate associations for 17 reproductive, hormonal and lifestyle characteristics and EOC risk by race/ethnicity among 10 924 women with invasive EOC (8918 Non-Hispanic Whites, 433 Hispanics, 911 Blacks, 662 Asian/Pacific Islanders) and 16 150 controls (13 619 Non-Hispanic Whites, 533 Hispanics, 1233 Blacks, 765 Asian/Pacific Islanders). Likelihood ratio tests were used to evaluate heterogeneity in the risk factor associations by race/ethnicity. Results: We observed statistically significant racial/ethnic heterogeneity for hysterectomy and EOC risk (P=0.008), where the largest odds ratio (OR) was observed in Black women [OR=1.64, 95% confidence interval (CI)=1.34-2.02] compared with other racial/ ethnic groups. Although not statistically significant, the associations for parity, firstdegree family history of ovarian or breast cancer, and endometriosis varied by race/ethnicity. Asian/Pacific Islanders had the greatest magnitude of association for parity (≥3 births: OR=0.38, 95% CI=0.28-0.54), and Black women had the largest ORs for family history (OR=1.77, 95% CI=1.42-2.21) and endometriosis (OR=2.42, 95% CI=1.65- 3.55). Conclusions: Although racial/ethnic heterogeneity was observed for hysterectomy, our findings support the validity of EOC risk factors across all racial/ethnic groups, and further suggest that any racial/ethnic population with a higher prevalence of a modifiable risk factor should be targeted to disseminate information about prevention.
UR - https://www.scopus.com/pages/publications/85050130094
U2 - 10.1093/IJE/DYX252
DO - 10.1093/IJE/DYX252
M3 - Article
C2 - 29211900
AN - SCOPUS:85050130094
SN - 0300-5771
VL - 47
SP - 460
EP - 472
JO - International Journal of Epidemiology
JF - International Journal of Epidemiology
IS - 2
ER -