Quantitative Static Secondary Ion Mass Spectrometry of Molecular Ions from 1-/5-3,4-Dihydroxyphenylalanine (l-DOPA) and Indolic Derivatives

Traditionally, static secondary ion mass spectrometry (SIMS) Is believed to yield qualitative information and very little quantitative Information. A method to obtain quantitative molecular ion data from organic static SIMS analysis of lOOPA and related compounds is presented. Linear calibration curves have been constructed by integrating the protonated molecular ion to sliver Ion peak area ratios over a known Ion dosage and plotting versus the original sample concentration.