Purpurinimides as photosensitizers: Effect of the presence and position of the substituents in the in vivo photodynamic efficacy

Ankur Rungta; Gang Zheng; Joseph R. Missert; William R. Potter; Thomas J. Dougherty; Ravindra K. Pandey

doi:10.1016/S0960-894X(00)00274-2

Purpurinimides as photosensitizers: Effect of the presence and position of the substituents in the in vivo photodynamic efficacy

Ankur Rungta
, Gang Zheng
, Joseph R. Missert
, William R. Potter
, Thomas J. Dougherty
, Ravindra K. Pandey

Institute for Lasers Photonics and Biophotonics

Roswell Park Cancer Institute

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Abstract

This study presents a novel approach for the regioselective synthesis of a series of alkyl ether analogues of purpurin-18-N-alkylimide. In the purpurinimide series, this is the first example which demonstrates that the presence and position of the substituents in the macrocycle makes a remarkable difference in the in vivo PDT efficacy. (C) 2000 Elsevier Science Ltd. All rights reserved.

Original language	English
Pages (from-to)	1463-1466
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	10
Issue number	13
DOIs	https://doi.org/10.1016/S0960-894X(00)00274-2
State	Published - Jul 3 2000

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abstract = "This study presents a novel approach for the regioselective synthesis of a series of alkyl ether analogues of purpurin-18-N-alkylimide. In the purpurinimide series, this is the first example which demonstrates that the presence and position of the substituents in the macrocycle makes a remarkable difference in the in vivo PDT efficacy. (C) 2000 Elsevier Science Ltd. All rights reserved.",

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T2 - Effect of the presence and position of the substituents in the in vivo photodynamic efficacy

AU - Rungta, Ankur

AU - Zheng, Gang

AU - Missert, Joseph R.

AU - Potter, William R.

AU - Dougherty, Thomas J.

AU - Pandey, Ravindra K.

PY - 2000/7/3

Y1 - 2000/7/3

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AB - This study presents a novel approach for the regioselective synthesis of a series of alkyl ether analogues of purpurin-18-N-alkylimide. In the purpurinimide series, this is the first example which demonstrates that the presence and position of the substituents in the macrocycle makes a remarkable difference in the in vivo PDT efficacy. (C) 2000 Elsevier Science Ltd. All rights reserved.

UR - https://www.scopus.com/pages/publications/0034601212

U2 - 10.1016/S0960-894X(00)00274-2

DO - 10.1016/S0960-894X(00)00274-2

M3 - Article

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AN - SCOPUS:0034601212

SN - 0960-894X

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JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 13

ER -

Purpurinimides as photosensitizers: Effect of the presence and position of the substituents in the in vivo photodynamic efficacy

Abstract

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