Punching Holes in an Enzyme

John P. Richard

doi:10.1016/j.chembiol.2009.09.003

Punching Holes in an Enzyme

John P. Richard

Chemistry

Research output: Contribution to journal › Short survey › peer-review

Abstract

Schramm and coworkers have punched holes into human purine nucleoside phosphorylase by substitution of glycine for aromatic amino acid residues at a protein lid. The results of studies on the enzymes with holes illuminate hidden chemistry that occurs at the enzyme active site.

Original language	English
Pages (from-to)	915-917
Number of pages	3
Journal	Chemistry and Biology
Volume	16
Issue number	9
DOIs	https://doi.org/10.1016/j.chembiol.2009.09.003
State	Published - Sep 25 2009

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10.1016/j.chembiol.2009.09.003

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title = "Punching Holes in an Enzyme",

abstract = "Schramm and coworkers have punched holes into human purine nucleoside phosphorylase by substitution of glycine for aromatic amino acid residues at a protein lid. The results of studies on the enzymes with holes illuminate hidden chemistry that occurs at the enzyme active site.",

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AB - Schramm and coworkers have punched holes into human purine nucleoside phosphorylase by substitution of glycine for aromatic amino acid residues at a protein lid. The results of studies on the enzymes with holes illuminate hidden chemistry that occurs at the enzyme active site.

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U2 - 10.1016/j.chembiol.2009.09.003

DO - 10.1016/j.chembiol.2009.09.003

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SP - 915

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JO - Chemistry and Biology

JF - Chemistry and Biology

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Punching Holes in an Enzyme

Abstract

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