Pump delivery of azidothymidine: Potential for constant concentrations and improved brain delivery

J. M. Gallo; L. N. Clark; J. T. Rubino

doi:10.1016/0168-3659(89)90093-X

Pump delivery of azidothymidine: Potential for constant concentrations and improved brain delivery

J. M. Gallo
, L. N. Clark
, J. T. Rubino

Pharmaceutical Sciences

University of Georgia
University of North Carolina at Chapel Hill

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Azidothymidine (AZT) was administered to rats by an osmotic pump and by a multiple-dose regimen. The cannula attached to the pump was placed in the external carotid artery to facilitate intraarterial delivery of AZT. Mean AZT serum and brain concentrations measured over seven days in the pump group were relatively constant and indicated an increase in brain uptake com- pared to animals that received the multiple-dose regimen.

Original language	English
Pages (from-to)	249-253
Number of pages	5
Journal	Journal of Controlled Release
Volume	9
Issue number	3
DOIs	https://doi.org/10.1016/0168-3659(89)90093-X
State	Published - Aug 1989

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title = "Pump delivery of azidothymidine: Potential for constant concentrations and improved brain delivery",

abstract = "Azidothymidine (AZT) was administered to rats by an osmotic pump and by a multiple-dose regimen. The cannula attached to the pump was placed in the external carotid artery to facilitate intraarterial delivery of AZT. Mean AZT serum and brain concentrations measured over seven days in the pump group were relatively constant and indicated an increase in brain uptake com- pared to animals that received the multiple-dose regimen.",

author = "Gallo, \{J. M.\} and Clark, \{L. N.\} and Rubino, \{J. T.\}",

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T2 - Potential for constant concentrations and improved brain delivery

AU - Gallo, J. M.

AU - Clark, L. N.

AU - Rubino, J. T.

PY - 1989/8

Y1 - 1989/8

N2 - Azidothymidine (AZT) was administered to rats by an osmotic pump and by a multiple-dose regimen. The cannula attached to the pump was placed in the external carotid artery to facilitate intraarterial delivery of AZT. Mean AZT serum and brain concentrations measured over seven days in the pump group were relatively constant and indicated an increase in brain uptake com- pared to animals that received the multiple-dose regimen.

AB - Azidothymidine (AZT) was administered to rats by an osmotic pump and by a multiple-dose regimen. The cannula attached to the pump was placed in the external carotid artery to facilitate intraarterial delivery of AZT. Mean AZT serum and brain concentrations measured over seven days in the pump group were relatively constant and indicated an increase in brain uptake com- pared to animals that received the multiple-dose regimen.

UR - https://www.scopus.com/pages/publications/0024385773

U2 - 10.1016/0168-3659(89)90093-X

DO - 10.1016/0168-3659(89)90093-X

M3 - Article

AN - SCOPUS:0024385773

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SP - 249

EP - 253

JO - Journal of Controlled Release

JF - Journal of Controlled Release

IS - 3

ER -

Pump delivery of azidothymidine: Potential for constant concentrations and improved brain delivery

Abstract

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