Properties of herpesvirus-induced “immediate early” polypeptides

R. T. Hay; J. Hay

doi:10.1016/0042-6822(80)90381-5

Properties of herpesvirus-induced “immediate early” polypeptides

R. T. Hay
, J. Hay

Microbiology and Immunology

Medical Research Council

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

It has been shown that both HSV1- and HSV2-induced “immediate early” polypeptides bind, with a range of affinities, to native calf thymus DNA in vitro. The biological relevance of this observation is reflected in cell fractionation studies, which demonstrate that HSV1-and HSV2-induced immediate early polypeptides migrate to the nucleus and there bind strongly to chromatin from infected cells.

Original language	English
Pages (from-to)	230-234
Number of pages	5
Journal	Virology
Volume	104
Issue number	1
DOIs	https://doi.org/10.1016/0042-6822(80)90381-5
State	Published - 1980

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10.1016/0042-6822(80)90381-5

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title = "Properties of herpesvirus-induced {\textquotedblleft}immediate early{\textquotedblright} polypeptides",

abstract = "It has been shown that both HSV1- and HSV2-induced {\textquotedblleft}immediate early{\textquotedblright} polypeptides bind, with a range of affinities, to native calf thymus DNA in vitro. The biological relevance of this observation is reflected in cell fractionation studies, which demonstrate that HSV1-and HSV2-induced immediate early polypeptides migrate to the nucleus and there bind strongly to chromatin from infected cells.",

author = "Hay, \{R. T.\} and J. Hay",

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AU - Hay, R. T.

AU - Hay, J.

PY - 1980

Y1 - 1980

N2 - It has been shown that both HSV1- and HSV2-induced “immediate early” polypeptides bind, with a range of affinities, to native calf thymus DNA in vitro. The biological relevance of this observation is reflected in cell fractionation studies, which demonstrate that HSV1-and HSV2-induced immediate early polypeptides migrate to the nucleus and there bind strongly to chromatin from infected cells.

AB - It has been shown that both HSV1- and HSV2-induced “immediate early” polypeptides bind, with a range of affinities, to native calf thymus DNA in vitro. The biological relevance of this observation is reflected in cell fractionation studies, which demonstrate that HSV1-and HSV2-induced immediate early polypeptides migrate to the nucleus and there bind strongly to chromatin from infected cells.

UR - https://www.scopus.com/pages/publications/0018895160

U2 - 10.1016/0042-6822(80)90381-5

DO - 10.1016/0042-6822(80)90381-5

M3 - Article

C2 - 6249025

AN - SCOPUS:0018895160

SN - 0042-6822

VL - 104

SP - 230

EP - 234

JO - Virology

JF - Virology

IS - 1

ER -

Properties of herpesvirus-induced “immediate early” polypeptides

Abstract

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