Prolonged plasma half‐life after oral isosorbide dinitrate in patients with angina pectoris.

HL Fung; JO Parker

doi:10.1111/j.1365-2125.1983.tb01560.x

Prolonged plasma half‐life after oral isosorbide dinitrate in patients with angina pectoris.

HL Fung
, JO Parker

Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

The plasma concentration of isosorbide dinitrate (ISDN) was monitored up to 24 h after a chronic oral dose of 60 mg in six patients with coronary artery disease. A terminal half‐life of 7.7 +/‐ 2.6 h (mean +/‐ s.d.) was observed. The presence of this prolonged disappearance phase provided at least a partial explanation for the observed accumulation of ISDN in plasma after chronic dosing on a six hourly regimen. 1983 The British Pharmacological Society

Original language	English
Pages (from-to)	746-748
Number of pages	3
Journal	British Journal of Clinical Pharmacology
Volume	15
Issue number	6
DOIs	https://doi.org/10.1111/j.1365-2125.1983.tb01560.x
State	Published - Jun 1983

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10.1111/j.1365-2125.1983.tb01560.x

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title = "Prolonged plasma half‐life after oral isosorbide dinitrate in patients with angina pectoris.",

abstract = "The plasma concentration of isosorbide dinitrate (ISDN) was monitored up to 24 h after a chronic oral dose of 60 mg in six patients with coronary artery disease. A terminal half‐life of 7.7 +/‐ 2.6 h (mean +/‐ s.d.) was observed. The presence of this prolonged disappearance phase provided at least a partial explanation for the observed accumulation of ISDN in plasma after chronic dosing on a six hourly regimen. 1983 The British Pharmacological Society",

author = "HL Fung and JO Parker",

year = "1983",

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T1 - Prolonged plasma half‐life after oral isosorbide dinitrate in patients with angina pectoris.

AU - Fung, HL

AU - Parker, JO

PY - 1983/6

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N2 - The plasma concentration of isosorbide dinitrate (ISDN) was monitored up to 24 h after a chronic oral dose of 60 mg in six patients with coronary artery disease. A terminal half‐life of 7.7 +/‐ 2.6 h (mean +/‐ s.d.) was observed. The presence of this prolonged disappearance phase provided at least a partial explanation for the observed accumulation of ISDN in plasma after chronic dosing on a six hourly regimen. 1983 The British Pharmacological Society

AB - The plasma concentration of isosorbide dinitrate (ISDN) was monitored up to 24 h after a chronic oral dose of 60 mg in six patients with coronary artery disease. A terminal half‐life of 7.7 +/‐ 2.6 h (mean +/‐ s.d.) was observed. The presence of this prolonged disappearance phase provided at least a partial explanation for the observed accumulation of ISDN in plasma after chronic dosing on a six hourly regimen. 1983 The British Pharmacological Society

UR - https://www.scopus.com/pages/publications/0020574425

U2 - 10.1111/j.1365-2125.1983.tb01560.x

DO - 10.1111/j.1365-2125.1983.tb01560.x

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C2 - 6871073

AN - SCOPUS:0020574425

SN - 0306-5251

VL - 15

SP - 746

EP - 748

JO - British Journal of Clinical Pharmacology

JF - British Journal of Clinical Pharmacology

IS - 6

ER -

Prolonged plasma half‐life after oral isosorbide dinitrate in patients with angina pectoris.

Abstract

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