Programmed nanoparticle aggregation using molecular beacons

Jonathan F. Lovell; Honglin Jin; Kenneth K. Ng; Gang Zheng

doi:10.1002/anie.201003846

Programmed nanoparticle aggregation using molecular beacons

Jonathan F. Lovell
, Honglin Jin
, Kenneth K. Ng
, Gang Zheng

Department of Biomedical Engineering

University of Toronto
Huazhong University of Science and Technology

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Out in the open: Hydrophobically modified molecular beacons were inserted into lipid nanoparticles. Upon addition of the target DNA to a solution of the lipid nanoparticles, irreversible nanoparticle aggregation occurred (see picture). This aggregation phenomenon results from the opening of the molecular beacons.

Original language	English
Pages (from-to)	7917-7919
Number of pages	3
Journal	Angewandte Chemie - International Edition
Volume	49
Issue number	43
DOIs	https://doi.org/10.1002/anie.201003846
State	Published - Oct 18 2010

Keywords

Aggregation
DNA
Lipoproteins
Molecular beacons
Nanoparticles

Access to Document

10.1002/anie.201003846

Cite this

@article{470aa24eee594e60986cd73f4a1d8557,

title = "Programmed nanoparticle aggregation using molecular beacons",

abstract = "Out in the open: Hydrophobically modified molecular beacons were inserted into lipid nanoparticles. Upon addition of the target DNA to a solution of the lipid nanoparticles, irreversible nanoparticle aggregation occurred (see picture). This aggregation phenomenon results from the opening of the molecular beacons.",

keywords = "Aggregation, DNA, Lipoproteins, Molecular beacons, Nanoparticles",

author = "Lovell, \{Jonathan F.\} and Honglin Jin and Ng, \{Kenneth K.\} and Gang Zheng",

year = "2010",

month = oct,

day = "18",

doi = "10.1002/anie.201003846",

language = "English",

volume = "49",

pages = "7917--7919",

journal = "Angewandte Chemie - International Edition",

issn = "1433-7851",

publisher = "John Wiley and Sons Ltd",

number = "43",

}

TY - JOUR

T1 - Programmed nanoparticle aggregation using molecular beacons

AU - Lovell, Jonathan F.

AU - Jin, Honglin

AU - Ng, Kenneth K.

AU - Zheng, Gang

PY - 2010/10/18

Y1 - 2010/10/18

N2 - Out in the open: Hydrophobically modified molecular beacons were inserted into lipid nanoparticles. Upon addition of the target DNA to a solution of the lipid nanoparticles, irreversible nanoparticle aggregation occurred (see picture). This aggregation phenomenon results from the opening of the molecular beacons.

AB - Out in the open: Hydrophobically modified molecular beacons were inserted into lipid nanoparticles. Upon addition of the target DNA to a solution of the lipid nanoparticles, irreversible nanoparticle aggregation occurred (see picture). This aggregation phenomenon results from the opening of the molecular beacons.

KW - Aggregation

KW - DNA

KW - Lipoproteins

KW - Molecular beacons

KW - Nanoparticles

UR - https://www.scopus.com/pages/publications/78349301641

U2 - 10.1002/anie.201003846

DO - 10.1002/anie.201003846

M3 - Article

C2 - 20853381

AN - SCOPUS:78349301641

SN - 1433-7851

VL - 49

SP - 7917

EP - 7919

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 43

ER -

Programmed nanoparticle aggregation using molecular beacons

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this