Progesterone receptor gene polymorphisms and risk of endometriosis: Results from an international collaborative effort

Aimee M. Near; Anna H. Wu; Claire Templeman; David J. Van Den Berg; Jennifer A. Doherty; Mary Anne Rossing; Ellen L. Goode; Julie M. Cunningham; Robert A. Vierkant; Brooke L. Fridley; Georgia Chenevix-Trench; Penelope M. Webb; Susanne Krüger Kjær; Estrid Hogdall; Simon A. Gayther; Susan J. Ramus; Usha Menon; Aleksandra Gentry-Maharaj; Joellen M. Schildkraut; Patricia G. Moorman; Rachel T. Palmieri; Roberta B. Ness; Kirsten Moysich; Daniel W. Cramer; Kathryn L. Terry; Allison F. Vitonis; Malcolm C. Pike; Andrew Berchuck; Celeste Leigh Pearce

doi:10.1016/j.fertnstert.2010.06.059

Progesterone receptor gene polymorphisms and risk of endometriosis: Results from an international collaborative effort

Aimee M. Near
, Anna H. Wu
, Claire Templeman
, David J. Van Den Berg
, Jennifer A. Doherty
, Mary Anne Rossing
, Ellen L. Goode
, Julie M. Cunningham
, Robert A. Vierkant
, Brooke L. Fridley
, Georgia Chenevix-Trench
, Penelope M. Webb
, Susanne Krüger Kjær
, Estrid Hogdall
, Simon A. Gayther
, Susan J. Ramus
, Usha Menon
, Aleksandra Gentry-Maharaj
, Joellen M. Schildkraut
, Patricia G. Moorman

Rachel T. Palmieri, Roberta B. Ness, Kirsten Moysich, Daniel W. Cramer, Kathryn L. Terry, Allison F. Vitonis, Malcolm C. Pike, Andrew Berchuck, Celeste Leigh Pearce

Department of Epidemiology and Environmental Health

Georgetown University
University of Southern California
Fred Hutchinson Cancer Research Center
Mayo Clinic Rochester, MN
Queensland Institute of Medical Research
Peter Maccallum Cancer Centre
Danish Cancer Society
University College London
Duke University
University of North Carolina at Chapel Hill
University of Texas Health Science Center at Houston
Brigham and Women’s Hospital

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Objective: To investigate the association between self-reported endometriosis and the putative functional promoter +331C/T single nucleotide polymorphism and the PROGINS allele. Design: Control subjects from ovarian cancer case-control studies participating in the international Ovarian Cancer Association Consortium. The majority of controls are drawn from population-based studies. Setting: An international ovarian cancer consortium including studies from Australia, Europe, and the United States. Patient(s): Five thousand eight hundred twelve white female controls, of whom 348 had endometriosis, from eight ovarian cancer case-control studies. Intervention(s): None. Main Outcome Measure(s): Genotypes for the +331C/T single nucleotide polymorphism and PROGINS allele and a history of endometriosis. Result(s): The occurrence of endometriosis was reduced in women carrying one or more copies of the +331 T allele (odds ratio = 0.65; 95% confidence interval: 0.43-0.98), whereas there was no association between the PROGINS allele and endometriosis (odds ratio = 0.94, 95% confidence interval 0.76-1.16). Conclusion(s): Additional studies of the +331C/T variant are warranted given the current finding and the equivocal results of previous studies. The +331 T allele has been shown to result in a reduced progesterone (P) receptor A to P receptor B ratio, and if the observed association with endometriosis is confirmed it would suggest that this ratio is important for this disease.

Original language	English
Pages (from-to)	40-45
Number of pages	6
Journal	Fertility and Sterility
Volume	95
Issue number	1
DOIs	https://doi.org/10.1016/j.fertnstert.2010.06.059
State	Published - Jan 2011

Keywords

Endometriosis
PROGINS
ovarian cancer
progesterone receptor

Access to Document

10.1016/j.fertnstert.2010.06.059

Cite this

Near, A. M., Wu, A. H., Templeman, C., Van Den Berg, D. J., Doherty, J. A., Rossing, M. A., Goode, E. L., Cunningham, J. M., Vierkant, R. A., Fridley, B. L., Chenevix-Trench, G., Webb, P. M., Kjær, S. K., Hogdall, E., Gayther, S. A., Ramus, S. J., Menon, U., Gentry-Maharaj, A., Schildkraut, J. M., ... Pearce, C. L. (2011). Progesterone receptor gene polymorphisms and risk of endometriosis: Results from an international collaborative effort. Fertility and Sterility, 95(1), 40-45. https://doi.org/10.1016/j.fertnstert.2010.06.059

@article{ec661aceceeb4fd0a136f38b08ff33aa,

title = "Progesterone receptor gene polymorphisms and risk of endometriosis: Results from an international collaborative effort",

abstract = "Objective: To investigate the association between self-reported endometriosis and the putative functional promoter +331C/T single nucleotide polymorphism and the PROGINS allele. Design: Control subjects from ovarian cancer case-control studies participating in the international Ovarian Cancer Association Consortium. The majority of controls are drawn from population-based studies. Setting: An international ovarian cancer consortium including studies from Australia, Europe, and the United States. Patient(s): Five thousand eight hundred twelve white female controls, of whom 348 had endometriosis, from eight ovarian cancer case-control studies. Intervention(s): None. Main Outcome Measure(s): Genotypes for the +331C/T single nucleotide polymorphism and PROGINS allele and a history of endometriosis. Result(s): The occurrence of endometriosis was reduced in women carrying one or more copies of the +331 T allele (odds ratio = 0.65; 95\% confidence interval: 0.43-0.98), whereas there was no association between the PROGINS allele and endometriosis (odds ratio = 0.94, 95\% confidence interval 0.76-1.16). Conclusion(s): Additional studies of the +331C/T variant are warranted given the current finding and the equivocal results of previous studies. The +331 T allele has been shown to result in a reduced progesterone (P) receptor A to P receptor B ratio, and if the observed association with endometriosis is confirmed it would suggest that this ratio is important for this disease.",

keywords = "Endometriosis, PROGINS, ovarian cancer, progesterone receptor",

author = "Near, \{Aimee M.\} and Wu, \{Anna H.\} and Claire Templeman and \{Van Den Berg\}, \{David J.\} and Doherty, \{Jennifer A.\} and Rossing, \{Mary Anne\} and Goode, \{Ellen L.\} and Cunningham, \{Julie M.\} and Vierkant, \{Robert A.\} and Fridley, \{Brooke L.\} and Georgia Chenevix-Trench and Webb, \{Penelope M.\} and Kj{\ae}r, \{Susanne Kr{\"u}ger\} and Estrid Hogdall and Gayther, \{Simon A.\} and Ramus, \{Susan J.\} and Usha Menon and Aleksandra Gentry-Maharaj and Schildkraut, \{Joellen M.\} and Moorman, \{Patricia G.\} and Palmieri, \{Rachel T.\} and Ness, \{Roberta B.\} and Kirsten Moysich and Cramer, \{Daniel W.\} and Terry, \{Kathryn L.\} and Vitonis, \{Allison F.\} and Pike, \{Malcolm C.\} and Andrew Berchuck and Pearce, \{Celeste Leigh\}",

year = "2011",

month = jan,

doi = "10.1016/j.fertnstert.2010.06.059",

language = "English",

volume = "95",

pages = "40--45",

journal = "Fertility and Sterility",

issn = "0015-0282",

publisher = "Elsevier Inc.",

number = "1",

}

Near, AM, Wu, AH, Templeman, C, Van Den Berg, DJ, Doherty, JA, Rossing, MA, Goode, EL, Cunningham, JM, Vierkant, RA, Fridley, BL, Chenevix-Trench, G, Webb, PM, Kjær, SK, Hogdall, E, Gayther, SA, Ramus, SJ, Menon, U, Gentry-Maharaj, A, Schildkraut, JM, Moorman, PG, Palmieri, RT, Ness, RB, Moysich, K, Cramer, DW, Terry, KL, Vitonis, AF, Pike, MC, Berchuck, A & Pearce, CL 2011, 'Progesterone receptor gene polymorphisms and risk of endometriosis: Results from an international collaborative effort', Fertility and Sterility, vol. 95, no. 1, pp. 40-45. https://doi.org/10.1016/j.fertnstert.2010.06.059

TY - JOUR

T1 - Progesterone receptor gene polymorphisms and risk of endometriosis

T2 - Results from an international collaborative effort

AU - Near, Aimee M.

AU - Wu, Anna H.

AU - Templeman, Claire

AU - Van Den Berg, David J.

AU - Doherty, Jennifer A.

AU - Rossing, Mary Anne

AU - Goode, Ellen L.

AU - Cunningham, Julie M.

AU - Vierkant, Robert A.

AU - Fridley, Brooke L.

AU - Chenevix-Trench, Georgia

AU - Webb, Penelope M.

AU - Kjær, Susanne Krüger

AU - Hogdall, Estrid

AU - Gayther, Simon A.

AU - Ramus, Susan J.

AU - Menon, Usha

AU - Gentry-Maharaj, Aleksandra

AU - Schildkraut, Joellen M.

AU - Moorman, Patricia G.

AU - Palmieri, Rachel T.

AU - Ness, Roberta B.

AU - Moysich, Kirsten

AU - Cramer, Daniel W.

AU - Terry, Kathryn L.

AU - Vitonis, Allison F.

AU - Pike, Malcolm C.

AU - Berchuck, Andrew

AU - Pearce, Celeste Leigh

PY - 2011/1

Y1 - 2011/1

N2 - Objective: To investigate the association between self-reported endometriosis and the putative functional promoter +331C/T single nucleotide polymorphism and the PROGINS allele. Design: Control subjects from ovarian cancer case-control studies participating in the international Ovarian Cancer Association Consortium. The majority of controls are drawn from population-based studies. Setting: An international ovarian cancer consortium including studies from Australia, Europe, and the United States. Patient(s): Five thousand eight hundred twelve white female controls, of whom 348 had endometriosis, from eight ovarian cancer case-control studies. Intervention(s): None. Main Outcome Measure(s): Genotypes for the +331C/T single nucleotide polymorphism and PROGINS allele and a history of endometriosis. Result(s): The occurrence of endometriosis was reduced in women carrying one or more copies of the +331 T allele (odds ratio = 0.65; 95% confidence interval: 0.43-0.98), whereas there was no association between the PROGINS allele and endometriosis (odds ratio = 0.94, 95% confidence interval 0.76-1.16). Conclusion(s): Additional studies of the +331C/T variant are warranted given the current finding and the equivocal results of previous studies. The +331 T allele has been shown to result in a reduced progesterone (P) receptor A to P receptor B ratio, and if the observed association with endometriosis is confirmed it would suggest that this ratio is important for this disease.

AB - Objective: To investigate the association between self-reported endometriosis and the putative functional promoter +331C/T single nucleotide polymorphism and the PROGINS allele. Design: Control subjects from ovarian cancer case-control studies participating in the international Ovarian Cancer Association Consortium. The majority of controls are drawn from population-based studies. Setting: An international ovarian cancer consortium including studies from Australia, Europe, and the United States. Patient(s): Five thousand eight hundred twelve white female controls, of whom 348 had endometriosis, from eight ovarian cancer case-control studies. Intervention(s): None. Main Outcome Measure(s): Genotypes for the +331C/T single nucleotide polymorphism and PROGINS allele and a history of endometriosis. Result(s): The occurrence of endometriosis was reduced in women carrying one or more copies of the +331 T allele (odds ratio = 0.65; 95% confidence interval: 0.43-0.98), whereas there was no association between the PROGINS allele and endometriosis (odds ratio = 0.94, 95% confidence interval 0.76-1.16). Conclusion(s): Additional studies of the +331C/T variant are warranted given the current finding and the equivocal results of previous studies. The +331 T allele has been shown to result in a reduced progesterone (P) receptor A to P receptor B ratio, and if the observed association with endometriosis is confirmed it would suggest that this ratio is important for this disease.

KW - Endometriosis

KW - PROGINS

KW - ovarian cancer

KW - progesterone receptor

UR - https://www.scopus.com/pages/publications/78650417362

U2 - 10.1016/j.fertnstert.2010.06.059

DO - 10.1016/j.fertnstert.2010.06.059

M3 - Article

C2 - 20719308

AN - SCOPUS:78650417362

SN - 0015-0282

VL - 95

SP - 40

EP - 45

JO - Fertility and Sterility

JF - Fertility and Sterility

IS - 1

ER -

Progesterone receptor gene polymorphisms and risk of endometriosis: Results from an international collaborative effort

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this