Profiling of pdr1 and msh2 in candida glabrata bloodstream isolates from a multicenter study in China

Xin Hou; Meng Xiao; He Wang; Shu Ying Yu; Ge Zhang; Yanan Zhao; Ying Chun Xu

doi:10.1128/AAC.00153-18

Profiling of pdr1 and msh2 in candida glabrata bloodstream isolates from a multicenter study in China

Xin Hou
, Meng Xiao
, He Wang
, Shu Ying Yu
, Ge Zhang
, Yanan Zhao
, Ying Chun Xu

Pharmacy

Chinese Academy of Medical Sciences
Graduate School of Peking Union Medical College
Beijing Key Laboratory for Mechanisms Research and Precision Diagnosis of Invasive Fungal Diseases

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

Among 158 Candida glabrata bloodstream isolates collected from numerous centers in China, a resistance to fluconazole was seen in 8.9%. Three isolates (1.9%) were resistant to all echinocandins. Multilocus sequence typing (MLST) revealed that sequence type 7 ([ST7] 65.8%) was the most common type, followed by ST3 (7.6%). PDR1 polymorphisms were associated with the acquisition of fluconazole resistance in C. glabrata isolates, while MSH2 polymorphisms were associated with the STs and microsatellite genotypes, irrespective of fluconazole resistance.

Original language	English
Article number	e00153-18
Journal	Antimicrobial Agents and Chemotherapy
Volume	62
Issue number	6
DOIs	https://doi.org/10.1128/AAC.00153-18
State	Published - Jun 2018

Keywords

Antifungal resistance
Candida glabrata sensu stricto
MSH2
PDR1

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10.1128/AAC.00153-18

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title = "Profiling of pdr1 and msh2 in candida glabrata bloodstream isolates from a multicenter study in China",

abstract = "Among 158 Candida glabrata bloodstream isolates collected from numerous centers in China, a resistance to fluconazole was seen in 8.9\%. Three isolates (1.9\%) were resistant to all echinocandins. Multilocus sequence typing (MLST) revealed that sequence type 7 ([ST7] 65.8\%) was the most common type, followed by ST3 (7.6\%). PDR1 polymorphisms were associated with the acquisition of fluconazole resistance in C. glabrata isolates, while MSH2 polymorphisms were associated with the STs and microsatellite genotypes, irrespective of fluconazole resistance.",

keywords = "Antifungal resistance, Candida glabrata sensu stricto, MSH2, PDR1",

author = "Xin Hou and Meng Xiao and He Wang and Yu, \{Shu Ying\} and Ge Zhang and Yanan Zhao and Xu, \{Ying Chun\}",

year = "2018",

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doi = "10.1128/AAC.00153-18",

language = "English",

volume = "62",

journal = "Antimicrobial Agents and Chemotherapy",

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T1 - Profiling of pdr1 and msh2 in candida glabrata bloodstream isolates from a multicenter study in China

AU - Hou, Xin

AU - Xiao, Meng

AU - Wang, He

AU - Yu, Shu Ying

AU - Zhang, Ge

AU - Zhao, Yanan

AU - Xu, Ying Chun

PY - 2018/6

Y1 - 2018/6

N2 - Among 158 Candida glabrata bloodstream isolates collected from numerous centers in China, a resistance to fluconazole was seen in 8.9%. Three isolates (1.9%) were resistant to all echinocandins. Multilocus sequence typing (MLST) revealed that sequence type 7 ([ST7] 65.8%) was the most common type, followed by ST3 (7.6%). PDR1 polymorphisms were associated with the acquisition of fluconazole resistance in C. glabrata isolates, while MSH2 polymorphisms were associated with the STs and microsatellite genotypes, irrespective of fluconazole resistance.

AB - Among 158 Candida glabrata bloodstream isolates collected from numerous centers in China, a resistance to fluconazole was seen in 8.9%. Three isolates (1.9%) were resistant to all echinocandins. Multilocus sequence typing (MLST) revealed that sequence type 7 ([ST7] 65.8%) was the most common type, followed by ST3 (7.6%). PDR1 polymorphisms were associated with the acquisition of fluconazole resistance in C. glabrata isolates, while MSH2 polymorphisms were associated with the STs and microsatellite genotypes, irrespective of fluconazole resistance.

KW - Antifungal resistance

KW - Candida glabrata sensu stricto

KW - MSH2

KW - PDR1

UR - https://www.scopus.com/pages/publications/85047636008

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DO - 10.1128/AAC.00153-18

M3 - Article

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AN - SCOPUS:85047636008

SN - 0066-4804

VL - 62

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 6

M1 - e00153-18

ER -

Profiling of pdr1 and msh2 in candida glabrata bloodstream isolates from a multicenter study in China

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Keywords

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