Abstract
The purpose of this study was to develop a model in swine for advanced coronary atherosclerosis and myocardial infarction. The approach was to combine a number of techniques that were thought to induce the development of atherosclerosis, including high-fat, high-cholesterol diets plus propylthiouracil and X-irradiation to the precordial region. The dose of X-irradiation that was used produced no significant changes by itself, but seemed only to enhance the effect of atherogenic diets. Among 28 swine fed the severe atherogenic diet and X-irradiated twice, 24 developed myocardial infarcts. All had advanced coronary atherosclerosis. Many died "suddenly" in the sense that no clinical signs of illness were observed prior to death. Coronary angiography was done on some swine and direct measurements of coronary blood flow on a few others. Coronary atherosclerosis and myocardial infarction were also produced in a few swine without propylthiouracil using a combination of a high-fat, high-cholesterol diet and X-irradiation.
| Original language | English |
|---|---|
| Pages (from-to) | 170-190 |
| Number of pages | 21 |
| Journal | Experimental and Molecular Pathology |
| Volume | 15 |
| Issue number | 2 |
| DOIs | |
| State | Published - Oct 1971 |
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