Problems of neoplastic disease: infections

Cancer patients may develop fulminant infections which present atypically and which may be caused by unusual microorganisms. Early diagnosis and correct aggressive therapy are necessary for achieving a favorable outcome in these patients. Resolution of the granulocytopenia and immunodepression resulting from the underlying neoplastic disease and its treatment will often result in rapid elimination of the infection. White blood cell transfusions, in combination with appropriate antibiotic therapy, may control or even eliminate serious infection occurring in patients with transient granulocytopenia. Isolation techniques and prophylactic antimicrobial drugs must be studied further to determine the extent of their usefulness. The development of chemotherapeutic agents with greater antineoplastic effect and less immunosuppression may facilitate a reduction of the infectious morbidity and mortality among cancer patients.