Abstract
Administration of methylandrostenediol, methyltestosterone and testosterone to hypophysectomized rats failed to produce the hypertensive vascular disease usually seen in normal animals receiving the same androgens. It is, therefore, evident that the pituitary, in addition to the adrenals, plays an essential role in the pathogenesis of androgen-induced hypertension and it is very likely that the constant stimulation of the adrenal gland by ACTH is essential to the development of such hypertensive disease.
| Original language | English |
|---|---|
| Pages (from-to) | 936-939 |
| Number of pages | 4 |
| Journal | Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.) |
| Volume | 141 |
| Issue number | 3 |
| DOIs | |
| State | Published - Dec 1972 |
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