Skip to main navigation Skip to search Skip to main content

Prediction of Incontinence after Robot-Assisted Radical Prostatectomy: Development and Validation of a 24-Month Incontinence Nomogram

  • Ruben M. Pinkhasov
  • , Timothy Lee
  • , Rogerio Huang
  • , Bonnie Berkley
  • , Alexandr M. Pinkhasov
  • , Nicole Dodge
  • , Matthew S. Loecher
  • , Gaybrielle James
  • , Elena Pop
  • , Kristopher Attwood
  • , James L. Mohler
  • Roswell Park Cancer Institute

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

Incontinence after robot-assisted radical prostatectomy (RARP) is feared by most patients with prostate cancer. Many risk factors for incontinence after RARP are known, but a paucity of data integrates them. Prospectively acquired data from 680 men who underwent RARP January 2008–December 2015 and met inclusion/exclusion criteria were queried retrospectively and then divided into model development (80%) and validation (20%) cohorts. The UCLA-PCI-Short Form-v2 Urinary Function questionnaire was used to categorize perfect continence (0 pads), social continence (1–2 pads), or incontinence (≥3 pads). The observed incontinence rates were 26% at 6 months, 7% at 12 months, and 3% at 24 months. Logistic regression was used for model development, with variables identified using a backward selection process. Variables found predictive included age, race, body mass index, and preoperative erectile function. Internal validation and calibration were performed using standard bootstrap methodology. Calibration plots and receiver operating curves were used to evaluate model performance. The initial model had 6-, 12-, and 24-month areas under the curves (AUCs) of 0.64, 0.66, and 0.80, respectively. The recalibrated model had 6-, 12-, and 24-month AUCs of 0.52, 0.52, and 0.76, respectively. The final model was superior to any single clinical variable for predicting the risk of incontinence after RARP.

Original languageEnglish
Article number1644
JournalCancers
Volume14
Issue number7
DOIs
StatePublished - Apr 1 2022

Keywords

  • Nomogram
  • Robot-assisted radical prostatectomy
  • Urinary incontinence

Fingerprint

Dive into the research topics of 'Prediction of Incontinence after Robot-Assisted Radical Prostatectomy: Development and Validation of a 24-Month Incontinence Nomogram'. Together they form a unique fingerprint.

Cite this