Precision Behavioral Management (PBM): A Novel Genetically Guided Therapy to Combat Reward Deficiency Syndrome (RDS) Relevant to the Opiate Crisis

Kenneth Blum; Alphonse Kenison Roy; Arwen Podesta; Edward J. Modestino; Bruce Steinberg; Marjorie C. Gondré-Lewis; David Baron; Panayotis K. Thanos; Lisa Lott; Sampada Badgaiyan; Jessica Valdez Ponce; Brent Boyett; David Siwicki; Mark Moran; Drew Edwards; Thomas McLaughlin; Eric R. Braverman; Thomas A. Simpatico; Mary Hauser; Bernard William Downs; Rajendra D. Badgaiyan

doi:10.1017/9781108632591.031

Precision Behavioral Management (PBM): A Novel Genetically Guided Therapy to Combat Reward Deficiency Syndrome (RDS) Relevant to the Opiate Crisis

Kenneth Blum
, Alphonse Kenison Roy
, Arwen Podesta
, Edward J. Modestino
, Bruce Steinberg
, Marjorie C. Gondré-Lewis
, David Baron
, Panayotis K. Thanos
, Lisa Lott
, Sampada Badgaiyan
, Jessica Valdez Ponce
, Brent Boyett
, David Siwicki
, Mark Moran
, Drew Edwards
, Thomas McLaughlin
, Eric R. Braverman
, Thomas A. Simpatico
, Mary Hauser
, Bernard William Downs

Rajendra D. Badgaiyan

Pharmacology and Toxicology

Western University of Health Sciences
Wright State University
University of Vermont
Tulane University
Curry College
Howard University
Geneus Health LLC
LLC
Lakeview Health
Center for Psychiatric Medicine
Path Foundation
Dominion Diagnostics LLC
Victory Nutrition International
Icahn School of Medicine at Mount Sinai
University of Texas Health Science Center at San Antonio

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

3 Scopus citations

Abstract

Reward Deficiency Syndrome (RDS) is an umbrella term for all drug and nondrug addictive behaviors, due to a dopamine deficiency, “hypodopaminergia.” There is an opioid-overdose epidemic in the USA, which may result in or worsen RDS. A paradigm shift is needed to combat a system that is not working. This shift involves the recognition of dopamine homeostasis as the ultimate treatment of RDS via precision, genetically guided KB220 variants, called Precision Behavioral Management (PBM). Recognition of RDS as an endophenotype and an umbrella term in the future DSM 6, following the Research Domain Criteria (RDoC), would assist in shifting this paradigm.

Original language	English
Title of host publication	The Cambridge Handbook of Substance and Behavioral Addictions
Publisher	Cambridge University Press
Pages	297-306
Number of pages	10
ISBN (Electronic)	9781108632591
ISBN (Print)	9781108427166
DOIs	https://doi.org/10.1017/9781108632591.031
State	Published - Jan 1 2020

Keywords

Dopamine homeostasis
GARStm
KB220 variants
Pain
Precision Addiction Management
Precision Behavioral Management
Reward Deficiency Syndrome (RDS)

Access to Document

10.1017/9781108632591.031

Cite this

Blum, K., Roy, A. K., Podesta, A., Modestino, E. J., Steinberg, B., Gondré-Lewis, M. C., Baron, D., Thanos, P. K., Lott, L., Badgaiyan, S., Ponce, J. V., Boyett, B., Siwicki, D., Moran, M., Edwards, D., McLaughlin, T., Braverman, E. R., Simpatico, T. A., Hauser, M., ... Badgaiyan, R. D. (2020). Precision Behavioral Management (PBM): A Novel Genetically Guided Therapy to Combat Reward Deficiency Syndrome (RDS) Relevant to the Opiate Crisis. In The Cambridge Handbook of Substance and Behavioral Addictions (pp. 297-306). Cambridge University Press. https://doi.org/10.1017/9781108632591.031

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title = "Precision Behavioral Management (PBM): A Novel Genetically Guided Therapy to Combat Reward Deficiency Syndrome (RDS) Relevant to the Opiate Crisis",

abstract = "Reward Deficiency Syndrome (RDS) is an umbrella term for all drug and nondrug addictive behaviors, due to a dopamine deficiency, “hypodopaminergia.” There is an opioid-overdose epidemic in the USA, which may result in or worsen RDS. A paradigm shift is needed to combat a system that is not working. This shift involves the recognition of dopamine homeostasis as the ultimate treatment of RDS via precision, genetically guided KB220 variants, called Precision Behavioral Management (PBM). Recognition of RDS as an endophenotype and an umbrella term in the future DSM 6, following the Research Domain Criteria (RDoC), would assist in shifting this paradigm.",

keywords = "Dopamine homeostasis, GARStm, KB220 variants, Pain, Precision Addiction Management, Precision Behavioral Management, Reward Deficiency Syndrome (RDS)",

author = "Kenneth Blum and Roy, \{Alphonse Kenison\} and Arwen Podesta and Modestino, \{Edward J.\} and Bruce Steinberg and Gondr{\'e}-Lewis, \{Marjorie C.\} and David Baron and Thanos, \{Panayotis K.\} and Lisa Lott and Sampada Badgaiyan and Ponce, \{Jessica Valdez\} and Brent Boyett and David Siwicki and Mark Moran and Drew Edwards and Thomas McLaughlin and Braverman, \{Eric R.\} and Simpatico, \{Thomas A.\} and Mary Hauser and Downs, \{Bernard William\} and Badgaiyan, \{Rajendra D.\}",

note = "Publisher Copyright: {\textcopyright} Cambridge University Press 2020.",

year = "2020",

month = jan,

day = "1",

doi = "10.1017/9781108632591.031",

language = "English",

isbn = "9781108427166",

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Blum, K, Roy, AK, Podesta, A, Modestino, EJ, Steinberg, B, Gondré-Lewis, MC, Baron, D, Thanos, PK, Lott, L, Badgaiyan, S, Ponce, JV, Boyett, B, Siwicki, D, Moran, M, Edwards, D, McLaughlin, T, Braverman, ER, Simpatico, TA, Hauser, M, Downs, BW & Badgaiyan, RD 2020, Precision Behavioral Management (PBM): A Novel Genetically Guided Therapy to Combat Reward Deficiency Syndrome (RDS) Relevant to the Opiate Crisis. in The Cambridge Handbook of Substance and Behavioral Addictions. Cambridge University Press, pp. 297-306. https://doi.org/10.1017/9781108632591.031

Precision Behavioral Management (PBM): A Novel Genetically Guided Therapy to Combat Reward Deficiency Syndrome (RDS) Relevant to the Opiate Crisis. / Blum, Kenneth; Roy, Alphonse Kenison; Podesta, Arwen et al.
The Cambridge Handbook of Substance and Behavioral Addictions. Cambridge University Press, 2020. p. 297-306.

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

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AU - Badgaiyan, Sampada

AU - Ponce, Jessica Valdez

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AU - Moran, Mark

AU - Edwards, Drew

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AU - Braverman, Eric R.

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AU - Downs, Bernard William

AU - Badgaiyan, Rajendra D.

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M3 - Chapter

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SN - 9781108427166

SP - 297

EP - 306

BT - The Cambridge Handbook of Substance and Behavioral Addictions

PB - Cambridge University Press

ER -

Precision Behavioral Management (PBM): A Novel Genetically Guided Therapy to Combat Reward Deficiency Syndrome (RDS) Relevant to the Opiate Crisis

Abstract

Keywords

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