Abstract
This review article briefly describes: (a) the advantages in developing multifunctional nanoparticles for cancer-imaging and therapy, (b) the advantages and limitations of most of the porphyrin-based compounds in fluorescence imaging and photodynamic therapy (PDT), (c) problems associated with current Food and Drug Administration (FDA) approved photosensitizers, (d) challenges in developing in vivo target-specific PDT agents, (e) development of porphyrin-based nuclear-imaging agents (PET, SPECT) with an option of PDT, (f) the importance of light dosimetry in PDT, (g) the role of whole body or local hyperthermia in enhancing tumor-uptake, tumor-imaging and phototherapy and finally, (h) the advantages of photosensitizer-gold nanocages (Ps-Au NC) in photoacoustic and PDT.
| Original language | English |
|---|---|
| Pages (from-to) | 109-134 |
| Number of pages | 26 |
| Journal | Journal of Porphyrins and Phthalocyanines |
| Volume | 19 |
| Issue number | 1-3 |
| DOIs | |
| State | Published - Jan 1 2015 |
Keywords
- cancer-imaging
- fluorescence
- magnetic resonance imaging
- multimodality agents
- nanoparticles
- nanoplatforms
- nuclear imaging
- photodynamic therapy
- theranostics
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