TY - JOUR
T1 - Pooled analyses of 13 prospective cohort studies on folate intake and colon cancer
AU - Kim, Dong Hyun
AU - Smith-Warner, Stephanie A.
AU - Spiegelman, Donna
AU - Yaun, Shiaw Shyuan
AU - Colditz, Graham A.
AU - Freudenheim, Jo L.
AU - Giovannucci, Edward
AU - Goldbohm, R. Alexandra
AU - Graham, Saxon
AU - Harnack, Lisa
AU - Jacobs, Eric J.
AU - Leitzmann, Michael
AU - Mannisto, Satu
AU - Miller, Anthony B.
AU - Potter, John D.
AU - Rohan, Thomas E.
AU - Schatzkin, Arthur
AU - Speizer, Frank E.
AU - Stevens, Victoria L.
AU - Stolzenberg-Solomon, Rachael
AU - Terry, Paul
AU - Toniolo, Paolo
AU - Weijenberg, Matty P.
AU - Willett, Walter C.
AU - Wolk, Alicja
AU - Zeleniuch-Jacquotte, Anne
AU - Hunter, David J.
PY - 2010/11
Y1 - 2010/11
N2 - Objective: Studies of folate intake and colorectal cancer risk have been inconsistent. We examined the relation with colon cancer risk in a series of 13 prospective studies. Methods: Study-and sex-specific relative risks (RRs) were estimated from the primary data using Cox proportional hazards models and then pooled using a random-effects model. Results: Among 725,134 participants, 5,720 incident colon cancers were diagnosed during follow-up. The pooled multivariate RRs (95% confidence interval [CI]) comparing the highest vs. lowest quintile of intake were 0.92 (95% CI 0.84-1.00, p-value, test for between-studies heterogeneity = 0.85) for dietary folate and 0.85 (95% CI 0.77-0.95, p-value, test for between-studies heterogeneity = 0.42) for total folate. Results for total folate intake were similar in analyses using absolute intake cutpoints (pooled multivariate RR = 0.87, 95% CI 0.78-0.98, comparing ≥560 mcg/days vs. <240 mcg/days, p-value, test for trend = 0.009). When analyzed as a continuous variable, a 2% risk reduction (95% CI 0-3%) was estimated for every 100 μg/day increase in total folate intake. Conclusion: These data support the hypothesis that higher folate intake is modestly associated with reduced risk of colon cancer.
AB - Objective: Studies of folate intake and colorectal cancer risk have been inconsistent. We examined the relation with colon cancer risk in a series of 13 prospective studies. Methods: Study-and sex-specific relative risks (RRs) were estimated from the primary data using Cox proportional hazards models and then pooled using a random-effects model. Results: Among 725,134 participants, 5,720 incident colon cancers were diagnosed during follow-up. The pooled multivariate RRs (95% confidence interval [CI]) comparing the highest vs. lowest quintile of intake were 0.92 (95% CI 0.84-1.00, p-value, test for between-studies heterogeneity = 0.85) for dietary folate and 0.85 (95% CI 0.77-0.95, p-value, test for between-studies heterogeneity = 0.42) for total folate. Results for total folate intake were similar in analyses using absolute intake cutpoints (pooled multivariate RR = 0.87, 95% CI 0.78-0.98, comparing ≥560 mcg/days vs. <240 mcg/days, p-value, test for trend = 0.009). When analyzed as a continuous variable, a 2% risk reduction (95% CI 0-3%) was estimated for every 100 μg/day increase in total folate intake. Conclusion: These data support the hypothesis that higher folate intake is modestly associated with reduced risk of colon cancer.
KW - Cohort studies
KW - Colon cancer
KW - Folate
KW - Meta-analysis
KW - Pooled analysis
UR - https://www.scopus.com/pages/publications/78449304532
U2 - 10.1007/s10552-010-9620-8
DO - 10.1007/s10552-010-9620-8
M3 - Article
C2 - 20820900
AN - SCOPUS:78449304532
SN - 0957-5243
VL - 21
SP - 1919
EP - 1930
JO - Cancer Causes and Control
JF - Cancer Causes and Control
IS - 11
ER -