Plasmonics-enhanced and optically modulated delivery of gold nanostars into brain tumor

Hsiangkuo Yuan; Christy M. Wilson; Jun Xia; Sarah L. Doyle; Shuqin Li; Andrew M. Fales; Yang Liu; Ema Ozaki; Kelly Mulfaul; Gabi Hanna; Gregory M. Palmer; Lihong V. Wang; Gerald A. Grant; Tuan Vo-Dinh

doi:10.1039/c3nr06770j

Plasmonics-enhanced and optically modulated delivery of gold nanostars into brain tumor

Hsiangkuo Yuan
, Christy M. Wilson
, Jun Xia
, Sarah L. Doyle
, Shuqin Li
, Andrew M. Fales
, Yang Liu
, Ema Ozaki
, Kelly Mulfaul
, Gabi Hanna
, Gregory M. Palmer
, Lihong V. Wang
, Gerald A. Grant
, Tuan Vo-Dinh

Department of Biomedical Engineering

Duke University
Trinity College Dublin
Children’s Health Ireland
Washington University St. Louis

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

Abstract

Plasmonics-active gold nanostars exhibiting strong imaging contrast and efficient photothermal transduction were synthesized for a novel pulsed laser-modulated plasmonics-enhanced brain tumor microvascular permeabilization. We demonstrate a selective, optically modulated delivery of nanoprobes into the tumor parenchyma with minimal off-target distribution.

Original language	English
Pages (from-to)	4078-4082
Number of pages	5
Journal	Nanoscale
Volume	6
Issue number	8
DOIs	https://doi.org/10.1039/c3nr06770j
State	Published - Apr 21 2014

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title = "Plasmonics-enhanced and optically modulated delivery of gold nanostars into brain tumor",

abstract = "Plasmonics-active gold nanostars exhibiting strong imaging contrast and efficient photothermal transduction were synthesized for a novel pulsed laser-modulated plasmonics-enhanced brain tumor microvascular permeabilization. We demonstrate a selective, optically modulated delivery of nanoprobes into the tumor parenchyma with minimal off-target distribution.",

author = "Hsiangkuo Yuan and Wilson, \{Christy M.\} and Jun Xia and Doyle, \{Sarah L.\} and Shuqin Li and Fales, \{Andrew M.\} and Yang Liu and Ema Ozaki and Kelly Mulfaul and Gabi Hanna and Palmer, \{Gregory M.\} and Wang, \{Lihong V.\} and Grant, \{Gerald A.\} and Tuan Vo-Dinh",

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month = apr,

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doi = "10.1039/c3nr06770j",

language = "English",

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pages = "4078--4082",

journal = "Nanoscale",

issn = "2040-3364",

publisher = "Royal Society of Chemistry",

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T1 - Plasmonics-enhanced and optically modulated delivery of gold nanostars into brain tumor

AU - Yuan, Hsiangkuo

AU - Wilson, Christy M.

AU - Xia, Jun

AU - Doyle, Sarah L.

AU - Li, Shuqin

AU - Fales, Andrew M.

AU - Liu, Yang

AU - Ozaki, Ema

AU - Mulfaul, Kelly

AU - Hanna, Gabi

AU - Palmer, Gregory M.

AU - Wang, Lihong V.

AU - Grant, Gerald A.

AU - Vo-Dinh, Tuan

PY - 2014/4/21

Y1 - 2014/4/21

N2 - Plasmonics-active gold nanostars exhibiting strong imaging contrast and efficient photothermal transduction were synthesized for a novel pulsed laser-modulated plasmonics-enhanced brain tumor microvascular permeabilization. We demonstrate a selective, optically modulated delivery of nanoprobes into the tumor parenchyma with minimal off-target distribution.

AB - Plasmonics-active gold nanostars exhibiting strong imaging contrast and efficient photothermal transduction were synthesized for a novel pulsed laser-modulated plasmonics-enhanced brain tumor microvascular permeabilization. We demonstrate a selective, optically modulated delivery of nanoprobes into the tumor parenchyma with minimal off-target distribution.

UR - https://www.scopus.com/pages/publications/84897433856

U2 - 10.1039/c3nr06770j

DO - 10.1039/c3nr06770j

M3 - Article

C2 - 24619405

AN - SCOPUS:84897433856

SN - 2040-3364

VL - 6

SP - 4078

EP - 4082

JO - Nanoscale

JF - Nanoscale

IS - 8

ER -

Plasmonics-enhanced and optically modulated delivery of gold nanostars into brain tumor

Abstract

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