Plasma dihydroxyphenylglycol (DHPG) in the in vivo assessment of human neuronal norepinephrine metabolism

Joseph L. Izzo; Dean A. Thompson; David Horwitz

doi:10.1016/0024-3205(85)90593-4

Plasma dihydroxyphenylglycol (DHPG) in the in vivo assessment of human neuronal norepinephrine metabolism

Joseph L. Izzo
, Dean A. Thompson
, David Horwitz

Medicine

University of Rochester
National Institutes of Health

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

We investigated the utility of deaminated norepinephrine (NE) metabolites in the study of human sympathetic nervous pathophysiology. Plasma levels of the NE metabolite dihydroxyphenylglycol (DHPG) appear to be related to intraneuronal NE stores. Plasma DHPG increases when sympathetic nervous activity or circulating NE increase and decreases when neuronal NE is depleted or neuronal NE reuptake is blocked. Changes in plasma dihydroxymandelic acid (DOMA) related less closely to changes in plasma NE. The coupling of measurements of plasma NE with its deaminated metabolites and DHPG may improve understanding of human NE metabolism and neuronal NE reuptake.

Original language	English
Pages (from-to)	1033-1038
Number of pages	6
Journal	Life Sciences
Volume	37
Issue number	11
DOIs	https://doi.org/10.1016/0024-3205(85)90593-4
State	Published - Sep 16 1985

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title = "Plasma dihydroxyphenylglycol (DHPG) in the in vivo assessment of human neuronal norepinephrine metabolism",

abstract = "We investigated the utility of deaminated norepinephrine (NE) metabolites in the study of human sympathetic nervous pathophysiology. Plasma levels of the NE metabolite dihydroxyphenylglycol (DHPG) appear to be related to intraneuronal NE stores. Plasma DHPG increases when sympathetic nervous activity or circulating NE increase and decreases when neuronal NE is depleted or neuronal NE reuptake is blocked. Changes in plasma dihydroxymandelic acid (DOMA) related less closely to changes in plasma NE. The coupling of measurements of plasma NE with its deaminated metabolites and DHPG may improve understanding of human NE metabolism and neuronal NE reuptake.",

author = "Izzo, \{Joseph L.\} and Thompson, \{Dean A.\} and David Horwitz",

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AU - Izzo, Joseph L.

AU - Thompson, Dean A.

AU - Horwitz, David

PY - 1985/9/16

Y1 - 1985/9/16

N2 - We investigated the utility of deaminated norepinephrine (NE) metabolites in the study of human sympathetic nervous pathophysiology. Plasma levels of the NE metabolite dihydroxyphenylglycol (DHPG) appear to be related to intraneuronal NE stores. Plasma DHPG increases when sympathetic nervous activity or circulating NE increase and decreases when neuronal NE is depleted or neuronal NE reuptake is blocked. Changes in plasma dihydroxymandelic acid (DOMA) related less closely to changes in plasma NE. The coupling of measurements of plasma NE with its deaminated metabolites and DHPG may improve understanding of human NE metabolism and neuronal NE reuptake.

AB - We investigated the utility of deaminated norepinephrine (NE) metabolites in the study of human sympathetic nervous pathophysiology. Plasma levels of the NE metabolite dihydroxyphenylglycol (DHPG) appear to be related to intraneuronal NE stores. Plasma DHPG increases when sympathetic nervous activity or circulating NE increase and decreases when neuronal NE is depleted or neuronal NE reuptake is blocked. Changes in plasma dihydroxymandelic acid (DOMA) related less closely to changes in plasma NE. The coupling of measurements of plasma NE with its deaminated metabolites and DHPG may improve understanding of human NE metabolism and neuronal NE reuptake.

UR - https://www.scopus.com/pages/publications/0022345038

U2 - 10.1016/0024-3205(85)90593-4

DO - 10.1016/0024-3205(85)90593-4

M3 - Article

C2 - 4033349

AN - SCOPUS:0022345038

SN - 0024-3205

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SP - 1033

EP - 1038

JO - Life Sciences

JF - Life Sciences

IS - 11

ER -

Plasma dihydroxyphenylglycol (DHPG) in the in vivo assessment of human neuronal norepinephrine metabolism

Abstract

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