Piperazinyl-linked fluoroquinolone dimers possessing potent antibacterial activity against drug-resistant strains of Staphylococcus aureus

Robert J. Kerns; Michael J. Rybak; Glenn W. Kaatz; Flamur Vaka; Raymond Cha; Richard G. Grucz; Veena U. Diwadkar; Tracey D. Ward

doi:10.1016/S0960-894X(03)00208-7

Piperazinyl-linked fluoroquinolone dimers possessing potent antibacterial activity against drug-resistant strains of Staphylococcus aureus

Robert J. Kerns
, Michael J. Rybak
, Glenn W. Kaatz
, Flamur Vaka
, Raymond Cha
, Richard G. Grucz
, Veena U. Diwadkar
, Tracey D. Ward

Pharmacy

University of Iowa
Wayne State University
VA Medical Center

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

Abstract

The synthesis of symmetric and asymmetric piperazinyl-linked dimers of the fluoroquinolone class of antibiotics is described. Specific dimers are shown to possess potent antibacterial activity against drug-resistant strains of Staphylococcus aureus, including strains possessing resistance due to the NorA multidrug efflux pump and a mutation in the quinolone resistance-determining region of topoisomerase IV.

Original language	English
Pages (from-to)	1745-1749
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	13
Issue number	10
DOIs	https://doi.org/10.1016/S0960-894X(03)00208-7
State	Published - May 19 2003

Access to Document

10.1016/S0960-894X(03)00208-7

Cite this

@article{7b725a55fc734b29ad9be6957d51861d,

title = "Piperazinyl-linked fluoroquinolone dimers possessing potent antibacterial activity against drug-resistant strains of Staphylococcus aureus",

abstract = "The synthesis of symmetric and asymmetric piperazinyl-linked dimers of the fluoroquinolone class of antibiotics is described. Specific dimers are shown to possess potent antibacterial activity against drug-resistant strains of Staphylococcus aureus, including strains possessing resistance due to the NorA multidrug efflux pump and a mutation in the quinolone resistance-determining region of topoisomerase IV.",

author = "Kerns, \{Robert J.\} and Rybak, \{Michael J.\} and Kaatz, \{Glenn W.\} and Flamur Vaka and Raymond Cha and Grucz, \{Richard G.\} and Diwadkar, \{Veena U.\} and Ward, \{Tracey D.\}",

year = "2003",

month = may,

day = "19",

doi = "10.1016/S0960-894X(03)00208-7",

language = "English",

volume = "13",

pages = "1745--1749",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Ltd",

number = "10",

}

TY - JOUR

T1 - Piperazinyl-linked fluoroquinolone dimers possessing potent antibacterial activity against drug-resistant strains of Staphylococcus aureus

AU - Kerns, Robert J.

AU - Rybak, Michael J.

AU - Kaatz, Glenn W.

AU - Vaka, Flamur

AU - Cha, Raymond

AU - Grucz, Richard G.

AU - Diwadkar, Veena U.

AU - Ward, Tracey D.

PY - 2003/5/19

Y1 - 2003/5/19

N2 - The synthesis of symmetric and asymmetric piperazinyl-linked dimers of the fluoroquinolone class of antibiotics is described. Specific dimers are shown to possess potent antibacterial activity against drug-resistant strains of Staphylococcus aureus, including strains possessing resistance due to the NorA multidrug efflux pump and a mutation in the quinolone resistance-determining region of topoisomerase IV.

AB - The synthesis of symmetric and asymmetric piperazinyl-linked dimers of the fluoroquinolone class of antibiotics is described. Specific dimers are shown to possess potent antibacterial activity against drug-resistant strains of Staphylococcus aureus, including strains possessing resistance due to the NorA multidrug efflux pump and a mutation in the quinolone resistance-determining region of topoisomerase IV.

UR - https://www.scopus.com/pages/publications/0038702176

U2 - 10.1016/S0960-894X(03)00208-7

DO - 10.1016/S0960-894X(03)00208-7

M3 - Article

C2 - 12729656

AN - SCOPUS:0038702176

SN - 0960-894X

VL - 13

SP - 1745

EP - 1749

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 10

ER -

Piperazinyl-linked fluoroquinolone dimers possessing potent antibacterial activity against drug-resistant strains of Staphylococcus aureus

Abstract

Access to Document

Other files and links

Fingerprint

Cite this