Physiological and pharmacological functions of Mrp2, Mrp3 and Mrp4 as determined from recent studies on gene-disrupted mice

Gary D. Kruh; Martin G. Belinsky; James M. Gallo; Kun Lee

doi:10.1007/s10555-007-9039-1

Physiological and pharmacological functions of Mrp2, Mrp3 and Mrp4 as determined from recent studies on gene-disrupted mice

Gary D. Kruh
, Martin G. Belinsky
, James M. Gallo
, Kun Lee

Pharmaceutical Sciences

Fox Chase Cancer Center

Research output: Contribution to journal › Review article › peer-review

79 Scopus citations

Abstract

The MRP family is composed of nine transporters, at least eight of which are lipophilic anion transporters that are capable of conferring resistance to various anticancer agents. Recently, mice with gene disruptions in Mrp2, Mrp3 and Mrp4 have been developed. This review will discuss insights into the physiological and pharmacological functions of Mrp2, Mrp3 and Mrp4 afforded by investigations of these new mouse models.

Original language	English
Pages (from-to)	5-14
Number of pages	10
Journal	Cancer and Metastasis Reviews
Volume	26
Issue number	1
DOIs	https://doi.org/10.1007/s10555-007-9039-1
State	Published - Mar 2007

Keywords

Hepatobiliary disposition
Multidrug resistance
Pharmacology
Transport

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10.1007/s10555-007-9039-1

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abstract = "The MRP family is composed of nine transporters, at least eight of which are lipophilic anion transporters that are capable of conferring resistance to various anticancer agents. Recently, mice with gene disruptions in Mrp2, Mrp3 and Mrp4 have been developed. This review will discuss insights into the physiological and pharmacological functions of Mrp2, Mrp3 and Mrp4 afforded by investigations of these new mouse models.",

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AU - Gallo, James M.

AU - Lee, Kun

PY - 2007/3

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AB - The MRP family is composed of nine transporters, at least eight of which are lipophilic anion transporters that are capable of conferring resistance to various anticancer agents. Recently, mice with gene disruptions in Mrp2, Mrp3 and Mrp4 have been developed. This review will discuss insights into the physiological and pharmacological functions of Mrp2, Mrp3 and Mrp4 afforded by investigations of these new mouse models.

KW - Hepatobiliary disposition

KW - Multidrug resistance

KW - Pharmacology

KW - Transport

UR - https://www.scopus.com/pages/publications/33947430596

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DO - 10.1007/s10555-007-9039-1

M3 - Review article

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Physiological and pharmacological functions of Mrp2, Mrp3 and Mrp4 as determined from recent studies on gene-disrupted mice

Abstract

Keywords

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