Phototoxicity of a core-modified porphyrin and induction of apoptosis

Youngjae You; Scott L. Gibson; Michael R. Detty

doi:10.1016/j.jphotobiol.2006.07.002

Phototoxicity of a core-modified porphyrin and induction of apoptosis

Youngjae You
, Scott L. Gibson
, Michael R. Detty

Pharmaceutical Sciences

University of Rochester
SUNY Buffalo

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

A core-modified porphyrin, 5-phenyl-10,15-bis(carboxylatomethoxyphenyl)-20-(2-thienyl)-21,23-dithiaporphyrin (IY69) was studied in vitro for photodynamic activity under a variety of experimental protocols. Variables included the cell line (the rodent mammary tumor cell line R3230AC or the human breast cancer cell line MCF-7), light fluence, time of exposure of the cell cultures to IY69, and the time post-irradiation for cell counting. The length of time cell cultures were exposed to IY69 impacted cellular accumulation and cellular localization, phototoxicity, and the apparent mode of cell death - apoptosis vs. necrosis.

Original language	English
Pages (from-to)	155-162
Number of pages	8
Journal	Journal of Photochemistry and Photobiology B: Biology
Volume	85
Issue number	3
DOIs	https://doi.org/10.1016/j.jphotobiol.2006.07.002
State	Published - Dec 1 2006

Keywords

Apoptosis
Breast cancer
Core-modified porphyrin
Photodynamic therapy

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10.1016/j.jphotobiol.2006.07.002

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title = "Phototoxicity of a core-modified porphyrin and induction of apoptosis",

abstract = "A core-modified porphyrin, 5-phenyl-10,15-bis(carboxylatomethoxyphenyl)-20-(2-thienyl)-21,23-dithiaporphyrin (IY69) was studied in vitro for photodynamic activity under a variety of experimental protocols. Variables included the cell line (the rodent mammary tumor cell line R3230AC or the human breast cancer cell line MCF-7), light fluence, time of exposure of the cell cultures to IY69, and the time post-irradiation for cell counting. The length of time cell cultures were exposed to IY69 impacted cellular accumulation and cellular localization, phototoxicity, and the apparent mode of cell death - apoptosis vs. necrosis.",

keywords = "Apoptosis, Breast cancer, Core-modified porphyrin, Photodynamic therapy",

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doi = "10.1016/j.jphotobiol.2006.07.002",

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T1 - Phototoxicity of a core-modified porphyrin and induction of apoptosis

AU - You, Youngjae

AU - Gibson, Scott L.

AU - Detty, Michael R.

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Y1 - 2006/12/1

N2 - A core-modified porphyrin, 5-phenyl-10,15-bis(carboxylatomethoxyphenyl)-20-(2-thienyl)-21,23-dithiaporphyrin (IY69) was studied in vitro for photodynamic activity under a variety of experimental protocols. Variables included the cell line (the rodent mammary tumor cell line R3230AC or the human breast cancer cell line MCF-7), light fluence, time of exposure of the cell cultures to IY69, and the time post-irradiation for cell counting. The length of time cell cultures were exposed to IY69 impacted cellular accumulation and cellular localization, phototoxicity, and the apparent mode of cell death - apoptosis vs. necrosis.

AB - A core-modified porphyrin, 5-phenyl-10,15-bis(carboxylatomethoxyphenyl)-20-(2-thienyl)-21,23-dithiaporphyrin (IY69) was studied in vitro for photodynamic activity under a variety of experimental protocols. Variables included the cell line (the rodent mammary tumor cell line R3230AC or the human breast cancer cell line MCF-7), light fluence, time of exposure of the cell cultures to IY69, and the time post-irradiation for cell counting. The length of time cell cultures were exposed to IY69 impacted cellular accumulation and cellular localization, phototoxicity, and the apparent mode of cell death - apoptosis vs. necrosis.

KW - Apoptosis

KW - Breast cancer

KW - Core-modified porphyrin

KW - Photodynamic therapy

UR - https://www.scopus.com/pages/publications/33750026947

U2 - 10.1016/j.jphotobiol.2006.07.002

DO - 10.1016/j.jphotobiol.2006.07.002

M3 - Article

C2 - 16905327

AN - SCOPUS:33750026947

SN - 1011-1344

VL - 85

SP - 155

EP - 162

JO - Journal of Photochemistry and Photobiology B: Biology

JF - Journal of Photochemistry and Photobiology B: Biology

IS - 3

ER -

Phototoxicity of a core-modified porphyrin and induction of apoptosis

Abstract

Keywords

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