PHOTOSENSITIZATION WITH BACTERIOCHLORINS

David Kessel; Kevin M. Smith; R. K. Pandey; F. ‐Y Shiau; Barbara Henderson

doi:10.1111/j.1751-1097.1993.tb09549.x

PHOTOSENSITIZATION WITH BACTERIOCHLORINS

David Kessel
, Kevin M. Smith
, R. K. Pandey
, F. ‐Y Shiau
, Barbara Henderson

Institute for Lasers Photonics and Biophotonics

Wayne State University
University of California at Davis
Roswell Park Cancer Institute

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

Abstract— Biophysical and photobiological properties of a group of bacteriochlorins were compared with efficacy of these products for photodynamic therapy of murine tumors. Predictive factors for selective photosensitization in vivo include affinity binding to lipoproteins greater than albumin, extinction coefficient at the wavelength of irradiation and tumor/skin distribution. Efficacy was correlated with circulating plasma levels of the different sensitizers but not with the photodynamic therapy response in cell culture.

Original language	English
Pages (from-to)	200-203
Number of pages	4
Journal	Photochemistry and Photobiology
Volume	58
Issue number	2
DOIs	https://doi.org/10.1111/j.1751-1097.1993.tb09549.x
State	Published - Aug 1993

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10.1111/j.1751-1097.1993.tb09549.x

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title = "PHOTOSENSITIZATION WITH BACTERIOCHLORINS",

abstract = "Abstract{\textemdash} Biophysical and photobiological properties of a group of bacteriochlorins were compared with efficacy of these products for photodynamic therapy of murine tumors. Predictive factors for selective photosensitization in vivo include affinity binding to lipoproteins greater than albumin, extinction coefficient at the wavelength of irradiation and tumor/skin distribution. Efficacy was correlated with circulating plasma levels of the different sensitizers but not with the photodynamic therapy response in cell culture.",

author = "David Kessel and Smith, \{Kevin M.\} and Pandey, \{R. K.\} and Shiau, \{F. ‐Y\} and Barbara Henderson",

year = "1993",

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AU - Shiau, F. ‐Y

AU - Henderson, Barbara

PY - 1993/8

Y1 - 1993/8

N2 - Abstract— Biophysical and photobiological properties of a group of bacteriochlorins were compared with efficacy of these products for photodynamic therapy of murine tumors. Predictive factors for selective photosensitization in vivo include affinity binding to lipoproteins greater than albumin, extinction coefficient at the wavelength of irradiation and tumor/skin distribution. Efficacy was correlated with circulating plasma levels of the different sensitizers but not with the photodynamic therapy response in cell culture.

AB - Abstract— Biophysical and photobiological properties of a group of bacteriochlorins were compared with efficacy of these products for photodynamic therapy of murine tumors. Predictive factors for selective photosensitization in vivo include affinity binding to lipoproteins greater than albumin, extinction coefficient at the wavelength of irradiation and tumor/skin distribution. Efficacy was correlated with circulating plasma levels of the different sensitizers but not with the photodynamic therapy response in cell culture.

UR - https://www.scopus.com/pages/publications/0027651707

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DO - 10.1111/j.1751-1097.1993.tb09549.x

M3 - Article

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AN - SCOPUS:0027651707

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ER -

PHOTOSENSITIZATION WITH BACTERIOCHLORINS

Abstract

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