Phosphorylation of muscle membranes: Identification of a membrane-bound protein kinase

Clifford G. Andrew; Allen D. Roses; Richard R. Almon; Stanley H. Appel

doi:10.1126/science.182.4115.927

Phosphorylation of muscle membranes: Identification of a membrane-bound protein kinase

Clifford G. Andrew
, Allen D. Roses
, Richard R. Almon
, Stanley H. Appel

Biological Sciences

Duke University

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

A membrane-bound protein kinase occurs in membranes derived from rat skeletal muscle and appears limited to a surface membrane fraction. The enzyme is magnesium dependent, is only minimally stimulated by cyclic nucleotides, and phosphorylates serine and to a lesser extent threonine residues of three membrane proteins with molecular weights of less than 30,000.

Original language	English
Pages (from-to)	927-929
Number of pages	3
Journal	Science
Volume	182
Issue number	4115
DOIs	https://doi.org/10.1126/science.182.4115.927
State	Published - 1973

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title = "Phosphorylation of muscle membranes: Identification of a membrane-bound protein kinase",

abstract = "A membrane-bound protein kinase occurs in membranes derived from rat skeletal muscle and appears limited to a surface membrane fraction. The enzyme is magnesium dependent, is only minimally stimulated by cyclic nucleotides, and phosphorylates serine and to a lesser extent threonine residues of three membrane proteins with molecular weights of less than 30,000.",

author = "Andrew, \{Clifford G.\} and Roses, \{Allen D.\} and Almon, \{Richard R.\} and Appel, \{Stanley H.\}",

year = "1973",

doi = "10.1126/science.182.4115.927",

language = "English",

volume = "182",

pages = "927--929",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

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TY - JOUR

T1 - Phosphorylation of muscle membranes

T2 - Identification of a membrane-bound protein kinase

AU - Andrew, Clifford G.

AU - Roses, Allen D.

AU - Almon, Richard R.

AU - Appel, Stanley H.

PY - 1973

Y1 - 1973

N2 - A membrane-bound protein kinase occurs in membranes derived from rat skeletal muscle and appears limited to a surface membrane fraction. The enzyme is magnesium dependent, is only minimally stimulated by cyclic nucleotides, and phosphorylates serine and to a lesser extent threonine residues of three membrane proteins with molecular weights of less than 30,000.

AB - A membrane-bound protein kinase occurs in membranes derived from rat skeletal muscle and appears limited to a surface membrane fraction. The enzyme is magnesium dependent, is only minimally stimulated by cyclic nucleotides, and phosphorylates serine and to a lesser extent threonine residues of three membrane proteins with molecular weights of less than 30,000.

UR - https://www.scopus.com/pages/publications/0015908712

U2 - 10.1126/science.182.4115.927

DO - 10.1126/science.182.4115.927

M3 - Article

C2 - 4355523

AN - SCOPUS:0015908712

SN - 0036-8075

VL - 182

SP - 927

EP - 929

JO - Science

JF - Science

IS - 4115

ER -

Phosphorylation of muscle membranes: Identification of a membrane-bound protein kinase

Abstract

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