Phase sensitivity analysis of a circadian rhythm gene network

Rudiyanto Gunawan; Francis J. Doyle

doi:10.1109/CDC.2005.1582735

Phase sensitivity analysis of a circadian rhythm gene network

Rudiyanto Gunawan
, Francis J. Doyle

Department of Chemical and Biological Engineering

University of California at Santa Barbara

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

2 Scopus citations

Abstract

Circadian rhythm synchronizes the daily activities of living organisms with the 24-hour earth rotation. The core of this clock is a transcriptional regulation of genes which produces an autonomous oscillation of 24-hour period. Despite the prevalence of oscillatory systems, sensitivity analysis of the key characteristics, such as period and phase, does not directly fit into the traditional framework for differential equations, which motivates the development of analyses aimed for these systems. This work focuses on the phase sensitivity analysis of circadian rhythm. Many of the concepts however can apply to oscillatory systems in general. Two examples of Drosophila circadian models illustrate the utilities of the developed analysis.

Original language	English
Title of host publication	Proceedings of the 44th IEEE Conference on Decision and Control, and the European Control Conference, CDC-ECC '05
Pages	3687-3692
Number of pages	6
DOIs	https://doi.org/10.1109/CDC.2005.1582735
State	Published - 2005
Event	44th IEEE Conference on Decision and Control, and the European Control Conference, CDC-ECC '05 - Seville, Spain Duration: Dec 12 2005 → Dec 15 2005

Publication series

Name	Proceedings of the 44th IEEE Conference on Decision and Control, and the European Control Conference, CDC-ECC '05
Volume	2005

Conference

Conference	44th IEEE Conference on Decision and Control, and the European Control Conference, CDC-ECC '05
Country/Territory	Spain
City	Seville
Period	12/12/05 → 12/15/05

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10.1109/CDC.2005.1582735

Cite this

Gunawan, R., & Doyle, F. J. (2005). Phase sensitivity analysis of a circadian rhythm gene network. In Proceedings of the 44th IEEE Conference on Decision and Control, and the European Control Conference, CDC-ECC '05 (pp. 3687-3692). Article 1582735 (Proceedings of the 44th IEEE Conference on Decision and Control, and the European Control Conference, CDC-ECC '05; Vol. 2005). https://doi.org/10.1109/CDC.2005.1582735

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title = "Phase sensitivity analysis of a circadian rhythm gene network",

abstract = "Circadian rhythm synchronizes the daily activities of living organisms with the 24-hour earth rotation. The core of this clock is a transcriptional regulation of genes which produces an autonomous oscillation of 24-hour period. Despite the prevalence of oscillatory systems, sensitivity analysis of the key characteristics, such as period and phase, does not directly fit into the traditional framework for differential equations, which motivates the development of analyses aimed for these systems. This work focuses on the phase sensitivity analysis of circadian rhythm. Many of the concepts however can apply to oscillatory systems in general. Two examples of Drosophila circadian models illustrate the utilities of the developed analysis.",

author = "Rudiyanto Gunawan and Doyle, \{Francis J.\}",

year = "2005",

doi = "10.1109/CDC.2005.1582735",

language = "English",

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series = "Proceedings of the 44th IEEE Conference on Decision and Control, and the European Control Conference, CDC-ECC '05",

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booktitle = "Proceedings of the 44th IEEE Conference on Decision and Control, and the European Control Conference, CDC-ECC '05",

note = "44th IEEE Conference on Decision and Control, and the European Control Conference, CDC-ECC '05 ; Conference date: 12-12-2005 Through 15-12-2005",

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Gunawan, R & Doyle, FJ 2005, Phase sensitivity analysis of a circadian rhythm gene network. in Proceedings of the 44th IEEE Conference on Decision and Control, and the European Control Conference, CDC-ECC '05., 1582735, Proceedings of the 44th IEEE Conference on Decision and Control, and the European Control Conference, CDC-ECC '05, vol. 2005, pp. 3687-3692, 44th IEEE Conference on Decision and Control, and the European Control Conference, CDC-ECC '05, Seville, Spain, 12/12/05. https://doi.org/10.1109/CDC.2005.1582735

Phase sensitivity analysis of a circadian rhythm gene network. / Gunawan, Rudiyanto; Doyle, Francis J.
Proceedings of the 44th IEEE Conference on Decision and Control, and the European Control Conference, CDC-ECC '05. 2005. p. 3687-3692 1582735 (Proceedings of the 44th IEEE Conference on Decision and Control, and the European Control Conference, CDC-ECC '05; Vol. 2005).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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N2 - Circadian rhythm synchronizes the daily activities of living organisms with the 24-hour earth rotation. The core of this clock is a transcriptional regulation of genes which produces an autonomous oscillation of 24-hour period. Despite the prevalence of oscillatory systems, sensitivity analysis of the key characteristics, such as period and phase, does not directly fit into the traditional framework for differential equations, which motivates the development of analyses aimed for these systems. This work focuses on the phase sensitivity analysis of circadian rhythm. Many of the concepts however can apply to oscillatory systems in general. Two examples of Drosophila circadian models illustrate the utilities of the developed analysis.

AB - Circadian rhythm synchronizes the daily activities of living organisms with the 24-hour earth rotation. The core of this clock is a transcriptional regulation of genes which produces an autonomous oscillation of 24-hour period. Despite the prevalence of oscillatory systems, sensitivity analysis of the key characteristics, such as period and phase, does not directly fit into the traditional framework for differential equations, which motivates the development of analyses aimed for these systems. This work focuses on the phase sensitivity analysis of circadian rhythm. Many of the concepts however can apply to oscillatory systems in general. Two examples of Drosophila circadian models illustrate the utilities of the developed analysis.

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DO - 10.1109/CDC.2005.1582735

M3 - Conference contribution

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SN - 9780780395688

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Gunawan R, Doyle FJ. Phase sensitivity analysis of a circadian rhythm gene network. In Proceedings of the 44th IEEE Conference on Decision and Control, and the European Control Conference, CDC-ECC '05. 2005. p. 3687-3692. 1582735. (Proceedings of the 44th IEEE Conference on Decision and Control, and the European Control Conference, CDC-ECC '05). doi: 10.1109/CDC.2005.1582735

Phase sensitivity analysis of a circadian rhythm gene network

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