Pharmacokinetic basis for predicting steady-state serum drug concentrations of imipramine from single dose data

C. Lindsay DeVane; Richard E. Wolin; William J. Jusko

Pharmacokinetic basis for predicting steady-state serum drug concentrations of imipramine from single dose data

C. Lindsay DeVane
, Richard E. Wolin
, William J. Jusko

Pharmaceutical Sciences

SUNY Buffalo
Millard Fillmore Gates Cir. Hospital

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

A promising therapeutic advance in drug therapy is the prediction of maintenance doses to achieve a targeted steady-state concentration based on a single serum concentration obtained after a test dose. The ability to make predictions in this manner has been based on a linear relationship. Theoretical considerations differ from experimental data and reveal that excessive accumulation of drug may occur outside of a limited and predetermined range of serum concentrations.

Original language	English
Pages (from-to)	353-357
Number of pages	5
Journal	Communications In Psychopharmacology
Volume	3
Issue number	5
State	Published - 1979

Cite this

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title = "Pharmacokinetic basis for predicting steady-state serum drug concentrations of imipramine from single dose data",

abstract = "A promising therapeutic advance in drug therapy is the prediction of maintenance doses to achieve a targeted steady-state concentration based on a single serum concentration obtained after a test dose. The ability to make predictions in this manner has been based on a linear relationship. Theoretical considerations differ from experimental data and reveal that excessive accumulation of drug may occur outside of a limited and predetermined range of serum concentrations.",

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journal = "Communications In Psychopharmacology",

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T1 - Pharmacokinetic basis for predicting steady-state serum drug concentrations of imipramine from single dose data

AU - DeVane, C. Lindsay

AU - Wolin, Richard E.

AU - Jusko, William J.

PY - 1979

Y1 - 1979

N2 - A promising therapeutic advance in drug therapy is the prediction of maintenance doses to achieve a targeted steady-state concentration based on a single serum concentration obtained after a test dose. The ability to make predictions in this manner has been based on a linear relationship. Theoretical considerations differ from experimental data and reveal that excessive accumulation of drug may occur outside of a limited and predetermined range of serum concentrations.

AB - A promising therapeutic advance in drug therapy is the prediction of maintenance doses to achieve a targeted steady-state concentration based on a single serum concentration obtained after a test dose. The ability to make predictions in this manner has been based on a linear relationship. Theoretical considerations differ from experimental data and reveal that excessive accumulation of drug may occur outside of a limited and predetermined range of serum concentrations.

UR - https://www.scopus.com/pages/publications/0018621673

M3 - Article

C2 - 548214

AN - SCOPUS:0018621673

SN - 0145-5699

VL - 3

SP - 353

EP - 357

JO - Communications In Psychopharmacology

JF - Communications In Psychopharmacology

IS - 5

ER -

Pharmacokinetic basis for predicting steady-state serum drug concentrations of imipramine from single dose data

Abstract

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