PHARMACOKINETIC AND CLINICAL STUDIES IN PATIENTS WITH CIMETIDINE-ASSOCIATED MENTAL CONFUSION

15 cases of cimetidine-associated mental confusion have been reported. In order that this syndrome might be investigated changes in mental status (M.S.) were correlated with serum concentrations and renal and hepatic function in 36 patients. 30 patients had no M.S. change on cimetidine and 6 had moderate to severe changes. These 6 patients had both renal and liver dysfunction (p<0·05), as well as cimetidine trough-concentrations of more than 1·25 μg/ml (p<0·05). The severity of M.S. changes increased as trough-concentrations rose. 5 patients had lumbar puncture. The cerebrospinal fluid: serum ratio of cimetidine concentrations was 0·24:1 and indicates that cimetidine passes the blood-brain barrier; it also raises the possibility that M.S. changes are due to blockade of histamine H₂-receptors in the central nervous system. Patients likely to have both raised trough-concentrations and mental confusion are those with both severe renal and hepatic dysfunction. They should be closely observed and should be given reduced doses of cimetidine.