Pharmacodynamic Modeling of Finasteride, a 5α‐Reductase Inhibitor

Hui C. Ko; William J. Jusko

doi:10.1002/j.1875-9114.1995.tb04389.x

Pharmacodynamic Modeling of Finasteride, a 5α‐Reductase Inhibitor

Hui C. Ko
, William J. Jusko

Pharmaceutical Sciences

SUNY Buffalo

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Finasteride is a 4‐azasteroid inhibitor of one isoenzyme of 5α‐reductases that converts testosterone to dihydrotestosterone (DHT). We characterized the time course of DHT concentrations. The following model was used to assess DHT pharmacodynamics: where joint fitting of three dose levels yielded k^oin = 28% change/hour, k_out = 0.28 hour¹, IC₅₀ = 0.012 ng/ml, and E_max = 0.7. The modification of a previous model with the maximum partial effect factor, E_max, may be useful in characterizing the pharmacodynamics of drugs with similar indirect mechanisms. 1995 Pharmacotherapy Publications Inc.

Original language	English
Pages (from-to)	509-511
Number of pages	3
Journal	Pharmacotherapy
Volume	15
Issue number	4
DOIs	https://doi.org/10.1002/j.1875-9114.1995.tb04389.x
State	Published - 1995

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abstract = "Finasteride is a 4‐azasteroid inhibitor of one isoenzyme of 5α‐reductases that converts testosterone to dihydrotestosterone (DHT). We characterized the time course of DHT concentrations. The following model was used to assess DHT pharmacodynamics: where joint fitting of three dose levels yielded koin = 28\% change/hour, kout = 0.28 hour1, IC50 = 0.012 ng/ml, and Emax = 0.7. The modification of a previous model with the maximum partial effect factor, Emax, may be useful in characterizing the pharmacodynamics of drugs with similar indirect mechanisms. 1995 Pharmacotherapy Publications Inc.",

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AU - Jusko, William J.

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AB - Finasteride is a 4‐azasteroid inhibitor of one isoenzyme of 5α‐reductases that converts testosterone to dihydrotestosterone (DHT). We characterized the time course of DHT concentrations. The following model was used to assess DHT pharmacodynamics: where joint fitting of three dose levels yielded koin = 28% change/hour, kout = 0.28 hour1, IC50 = 0.012 ng/ml, and Emax = 0.7. The modification of a previous model with the maximum partial effect factor, Emax, may be useful in characterizing the pharmacodynamics of drugs with similar indirect mechanisms. 1995 Pharmacotherapy Publications Inc.

UR - https://www.scopus.com/pages/publications/0029051877

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ER -

Pharmacodynamic Modeling of Finasteride, a 5α‐Reductase Inhibitor

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