@inproceedings{894694c461cd4896979eac6d7c927888,
title = "Pharmaceutical crystal engineering in microfluidic emulsions",
abstract = "In this paper, we present a crystallization platform that couples capillary microflsuidics-based emulsion generation with evaporative crystallization for the production of monodisperse spherical agglomerates of glycine, a model molecule for API crystallization studies. This platform enables us to produce exquisitely uniform spherical agglomerates (SAs) in industrially relevant size ranges. Furthermore, on-line high-speed imaging provides valuable and hitherto unmatched insights into crystallization dynamics within emulsion droplets. We show that our system can be extended to other analogous molecules in a straightforward fashion. We also discuss several crucial aspects of crystallization dynamics that could extend our system's applicability to industrially relevant solutes.",
keywords = "Capillary microfluidics, Pharmaceuticals, Spherical crystallization",
author = "Toldy, \{Arpad I.\} and Abu, \{Abu Zayed\} and Lu Zheng and \{Alan Hatton\}, T. and Rudiyanto Gunawan and Raj Rajagopalan and Khan, \{Saif A.\}",
year = "2012",
language = "English",
isbn = "9780979806452",
series = "Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012",
publisher = "Chemical and Biological Microsystems Society",
pages = "1216--1218",
booktitle = "Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012",
note = "16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012 ; Conference date: 28-10-2012 Through 01-11-2012",
}